Searchable abstracts of presentations at key conferences in endocrinology

ea0003p12 | Clinical Case Reports | BES2002

The perils of low dose locally delivered steroids

Browne D , Cummings M , Murdoch S , Cook L , Meeking D

Clinical practice suggests that low dose steroid treatment delivered locally to the site of action may rarely lead to disturbances of the hypothalamic-pituitary-adrenal axis. We present three clinical examples:Case 1: A 72 yr old man with a history of severe sinusitis was referred because of three episodes of profound anorexia, vomiting and proximal muscle weakness which coincided with discontinuing his Betnesol (betamethasone sodium phosphate 0.1%) nose...

ea0003p15 | Clinical Case Reports | BES2002

Hyperparathyroidism and polycythaemia

Kamalakannan D , Baskar V , Buch H , Barton D , Singh B

IntroductionHypercalcemia is a recognised feature of parathyroid and neoplastic disorders and similarly erythrocytosis is recognised in some benign and malignant neoplasm.Case reportA 71-year-old man presented to the admissions unit with an episode of collapse. No significant neurological or cardiovascular cause was identified. The results of his routine investigation revealed haemoglobin of 19.7g/dl and a ...

ea0003p123 | Endocrine Tumours and Neoplasia | BES2002

An evalution of endocrine assessment of patients with pituitary tumours prior to tertiary referral

Baskar V , Barton D , Kamalakannan D , Singh B

The 1997 working party recommendations for the management of patients with pituitary tumours suggest formal assessment by an endocrinologist prior to tertiary referral. We have examined the extent of endocrine assessment in such patients performed both by endocrine and non-endocrine specialists in a large district general hospital. Using ICD 9 & 10 coding records on patients discharged between 1993 and 2000, we identified 60 patients with pituitary pathology. Of these, 1...

ea0003p273 | Steroids | BES2002

Long-term overall success after transsphenoidal surgery for Cushing's disease: Time for a reappraisal of therapy?

Kennedy A , Wiggam M , Hadden D , Mccance D , Sheridan B , Atkinson A

There have been few reports of long term remission rates after transsphenoidal surgery for Cushing's disease which incorporate both initial failure rates and later relapse rates. We have studied this in patients diagnosed and treated between 1979 and 2000. An early post-operative 0800h serum cortisol was measured 24h after the last dose of hydrocortisone, in addition to a low dose dexamethasone suppression test. Of the initial 63 patients, 18 did not achieve remission after su...

ea0002p63 | Neuroendocrinology | SFE2001

The effect of metabolites of MDMA ('ecstasy') on the release of vasopressin in vitro

Forsling M , Fallon J , Shah D , Kicman A , Hutt A , Cowan D

Vasopressin release is stimulated following the administration of 3,4-methylenedioxymethamphetamine (MDMA ) in man. MDMA and a major metabolite, 4-hydroxy-3-methoxymethamphetamine (HMMA), have also been shown to stimulate neurohypophysial hormone release in vitro. A study has now been performed comparing the response to four other metabolites with the parent compound. Hypothalami obtained from male Wistar rats were exposed to medium alone (B1) and the medium containing ...

ea0002p93 | Steroids | SFE2001

AMBULANT ALDOSTERONE/ ACTIVE RENIN RATIOS AS A SCREEN FOR CONN'S SYNDROME; INFLUENCE OF DRUG THERAPY

Armston A , Waller D , Krentz A , Sandeman D , Leatherdale B , Wood P

Primary hyperaldosteronism ('Conn's syndrome') may have a prevalence as high as 10% in hypertensive patients, and in some cases there may not be obvious hypokalaemia. Recently the use of a single aldosterone/ renin ('A/R') ratio has been advocated as a screening test for Conn's, and less influence by anti-hypertensive drug therapy has been claimed.We have established a cut-off for ambulant A/R ratios of 25 ng/mU using the DPC'Coat-a-Count' aldosterone method and the Nichols 'A...

ea0068p8 | Abstracts | UKINETS2019

Audit of the appropriateness and outcomes of 24-hour urinary 5-HIAA testing in a UK general hospital

Higginson Kieren , Pritchard D Mark

Introduction: Some functional neuroendocrine tumours (NETs) secrete serotonin, leading to the symptoms of carcinoid syndrome (e.g. diarrhoea and flushing). In this condition, increased urinary concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) are often detected. Measurement of 24-hour urinary 5-HIAA is therefore used to investigate patients with confirmed or suspected carcinoid syndrome. We sought to evaluate the appropriateness and effectiveness o...

ea0059ep111 | Thyroid | SFEBES2018

Protean Presentations of Severe Hypothyroidism: Decompensated Liver Disease as an Unusual Co-presentation

Costa Ryan D. , Nagi Dinesh

We report a 51-year old lady presenting to hospital with a 3 week history of abdominal and peripheral swelling. Mentation was slow and noted to be pale on admission. She also reported feeling cold, lethargic, reduced exercise tolerance and constipation. She had no prior medical problems, no regular medications and working till the day prior to admission in a garden centre. She was an ex-smoker, teetotal and there was a family history of hypothyroidism. Physical assessment reve...

ea0029p481 | Developmental endocrinology | ICEECE2012

Regulation of trophoblast 11β-hydroxysteroid dehydrogenase type 2 expression and role of corticotropin-releasing hormone

Hein A. , Vatish M. , Grammatopoulos D.

The formation of the placental syncytiotrophoblast through trophoblast differentiation is a key cellular event, essential for successful embryonic implantation, oxygen/nutrient transport and secretion of placental hormones necessary for fetal development. Trophoblast differentiation alters expression of various molecules with important roles in placental biology, including 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), the major component of the placental glucoc...

ea0029p486 | Developmental endocrinology | ICEECE2012

Post prandial gut hormones: novel activators and regulators of innate immune function

Hogan A. , O'Connell J. , O'Shea D.

Invariant natural killer T (iNKT) cells are key innate immune cells implicated in the pathogenesis of many diseases. Glucagon-like peptide-1 (GLP-1) is an incretin hormone implicated in regulating blood glucose and body weight. We recently demonstrated that GLP-1 is a regulator of iNKT cell function and that inflammatory conditions such as psoriasis, rheumatoid arthritis and ulcerative colitis improve following GLP-1 therapy. GLP-1 is one of several post-prandial gut hormones,...