Searchable abstracts of presentations at key conferences in endocrinology

ea0003p27 | Clinical Case Reports | BES2002

A case of pseudohypoparathyroidism with diagnostic dilemmas

Kennedy A , Hadden D , Hunter S

A 22 year old female was referred for investigation of cramps in both hands, and tingling in her face. She also complained of lethargy and occasional dizziness. Routine testing by her General Practioner had demonstrated a low serum calcium. She had had problems at birth with hypocalcaemia. A diagnosis of hypothyroidism had been made previously, but she had stopped taking thyroxine medication. Both her mother and grandmother had required intermittent calcium supplementation. On...

ea0003p35 | Clinical Case Reports | BES2002

Iatrogenic Acromegaly

Tuthill A , McKenna T , O'Shea D

Acromegaly is a condition resulting from the action of excess growth hormone. We report the first case of acromegaly occurring in an individual as a result of growth hormone replacement therapy.Features of acromegaly developed in a forty-year old gentleman who was commenced on growth hormone replacement in 1993 following resection of a craniopharyngioma. Prior to commencing therapy, peak growth hormone response to insulin-induced hypoglycaemia was less ...

ea0003p237 | Signalling | BES2002

Analysis of GR/NFkB interactions in living cells

Garside H , Stevens A , Ray D

Glucocorticoids (Gc) are highly potent anti-inflammatory agents. They act through the glucocorticoid receptor (GR), a protein capable of multiple protein interactions. The pro-inflammatory cytokines, TNF-a and IL-1 signal, in part, through activation of NF-kB. Nf-kB transactivation is inhibited by activated GR. It has been suggested that the GR, and the p65 (RelA) component of NF-kB form a direct contact independent of Gc ligand, and that Gc binding results in inhibition of p6...

ea0003p254 | Steroids | BES2002

Hypoglycaemia and Addison's disease - cause or association?

Kennedy A , Hadden D , Hunter S

J. Q. presented initially at age 2 years with hypoglycaemia following a six-hour fast prior to an elective surgical procedure. Investigations demonstrated a low plasma glucose (1.6mmol/l), elevated beta Hydroxybutyrate (5.2 mmol/l), normal lactate (1.09nmol/l) and a detectable serum insulin level (2.5 mU/L). A plasma amino-acid profile was normal. The dorsum of his hands and the extensor region of his arms were noted to be pigmented, however a synacthen test at that time, ind...

ea0056gp20 | Adrenal Case reports | ECE2018

Cushing’s syndrome revealing carney complex due to novel PRKAR1A mutation

Zhang Catherine D , Bancos Irina

Introduction: Carney complex (CNC) is a rare multiple neoplasia syndrome characterized by pigmented lesions of the skin and mucosa in association with various endocrine and non-endocrine tumors. The disease can be inherited in an autosomal-dominant fashion or occur sporadically due to novel mutations in the PRKAR1A gene. Primary pigmented nodular adrenocortical disease (PPNAD) is a common endocrine manifestation of CNC.Case description: A 20-year-old wom...

ea0002oc16 | Neuroendocrinology | SFE2001

Efficacy of the new Long-Acting Lanreotide Formulation (Lanreotide Autogel) in Patients with Acromegaly

Cullen D , Grossman A , Reckless J

Lanreotide (LAN) Autogel, a new aqueous preparation of lanreotide acetate, was administered by deep sc injection every 4 weeks to patients with acromegaly (54 males, 53 females, mean age 53 plus/minus 1 year) who had previously been responsive to im SR LAN 30 mg microparticles. Patients who had been treated with at least 4 im injections of SR LAN 30 mg every 14 (49%), 10 (32%) or 7 days (20%) for at least 3 months and had a mean GH level <10 ng/ml, were switched to LAN Auto...

ea0029p236 | Calcium &amp; Vitamin D metabolism | ICEECE2012

Bone biomarkers, body composition and metabolic profile in patients with primary hyperparathyroidism

Cvijovic G. , Micic D. , Kendereski A. , Zoric S. , Sumarac-Dumanovic M. , Stamenkovic-Pejkovic D. , Jeremic D.

Objective: Primary hyperparathyroidism (PHPT) is systemic disease affecting bone metabolism and glucose homeostasis. Patients with PHPT are insulin resistant and have atherogenic dyslipidaemia. Osteocalcin (OC) is bone biomarker associated with increased insulin secretion and insulin sensitivity and decreased visceral fat The aim of our study was to evaluate the body composition and levels of bone biomarkers (osteocalcin and betaCTx), insulin sensitivity and lipids in patients...

ea0029p436 | Clinical case reports - Thyroid/Others | ICEECE2012

Hypoparathyroidism - a rare cause of heart failure

Zoric S. , Micic D. , Kendereski A. , Cvijovic G. , Sumarac-Dumanovic M. , Stamenkovic-Pejkovic D. , Jeremic D.

Introduction: Calcium plays a key role in myocardial contractions and relaxation. Heart failure induced by hypocalcemia is rare but potentially reversible case.Case report: We present the case of 50 years old woman with muscle cramps, cataract, chest pain and dyspnea that lasts 2 years. In regional health center she was treated as psychiatric patient and COPD. Last few months she became extremely malaise with crural edemas and walking distance of 100 m. ...

ea0029p1421 | Pituitary Clinical | ICEECE2012

Audit of pituitary dysfunction after traumatic brain injury: caution in interpretation of glucagon stimulation test in diagnosis of GH and ACTH deficiency.

Tenorio Jimenez C. , Niemi M. , Malik A. , Papadopoulou D. , Ham T. , Baxter D. , Sharp D. , Goldstone A.

Introduction: Traumatic brain injury (TBI) is the leading cause of death and disability in young adults. It is important to recognise pituitary dysfunction following TBI as it can cause significant morbidity.Methods: 179 TBI patients (137 males) age 41.0±15.7 years (17.6–88.1 years) attended Charing Cross Hospital clinic (July 2009–August 2011). Median time since TBI was 0.27years (0.05–46.5 years, 26% >1 years). 34% had an intrac...

ea0011p86 | Clinical case reports | ECE2006

A case of bacterial endocarditis in a patient with acromegaly

Bassotti G , Di Sarra D , Pietrobono D , D’Amico T , Gargiulo P , Tamburrano G

Objective and importance: Among pathologies associated with acromegaly, have great importance both colon benignant neoformations such polyposis, and cardiovascular complications such as miocardic hypertrophy, arterial hypertension, coronaropathy and valvulopathy.Clinical presentation: We report a case of 74-years-old woman with acromegaly, diabetes mellitus type II and hyperthyroidism, who was admitted at our clinic with symptoms of chronic febricula wit...