Searchable abstracts of presentations at key conferences in endocrinology

ea0026s13.1 | Endocrine response to critical illness | ECE2011

The HPA axis in critical illness

Annane D

The role of the hypothalamic–pituitary adrenal axis in host response to an infection is crucial. The initial inflammatory response to sepsis activates the endogenous release of cortisol which in turn will modulate the synthesis and release of both pro- and anti-inflammatory mediators to restrict inflammation to the infected tissues. However, a number of factors including vascular or ischemic damage, inflammation and apoptosis within the hypothalamic–pituitary adrenal...

ea0026p504 | Bone/calcium/Vitamin D | ECE2011

Sex-specific response of mammalian bone in vivo and in vitro to estrogens and to androgens

Somjen D

Rat and mice bones in vivo and their derived cell cultures in vitro respond sex-specifically to gonadal steroids (GS) by stimulating DNA synthesis (DNA) and the specific activity of creatine kinase (CK; a hormone receptor response marker). Similar results were demonstrated in cultured human male or female-derived bone cells (Obs); female Obs responded only to estradiol-17β (E2) whereas male Obs responded only to dihydrotestosterone (DHT) by stimul...

ea0025sig2.4 | Obesity special interest group | SFEBES2011

Bariatric surgery: a cure for diabetes?

Johnston D

Type 2 diabetes is increasing in prevalence and is associated with, amongst others, premature CVD, retinopathy and kidney failure. The aim of care is to minimise the complications through euglycaemia but in the long term, this is rarely possible. Treatment of hypertension and dyslipidaemia also has benefit and patients are often consigned to a lifetime of polypharmacy. Quality of life is affected, especially in those with complications and in those who need treatment with insu...

ea0019s21 | What's Wnt? A novel signalling pathway in endocrinology | SFEBES2009

Paracrine signalling in the ovary: the role of Wnt

Boerboom D

Wnt signaling has well-established roles in gonadal development, notably being required for proper sex determination. More recently, a series of descriptive studies has shown the expression of various Wnts and Wnt signaling pathway components in adult ovaries during different stages of follicular development. To determine the potential role of WNT4 in follicle development, a mouse strain bearing a floxed Wnt4 allele was created using standard gene targeting techniques, ...

ea0019s66 | Sex hormone replacement | SFEBES2009

Androgen replacement in female to male transgender

Wright D

Forty-four-year-old transgender – female to male who underwent surgery for gender reassignment including hysterectomy, oophrectomy and mastectomy.He has been on testosterone replacement since 2003, initially oral, then sustanon 250 mg IM injection 2 weekly which was self-administered. He was keen on long-acting testosterone injections (Nebido) so was referred to our endocrine service, as his GP was reluctant to prescribe testosterone replacement, as...

ea0019s86 | (1) | SFEBES2009

Jade, sex and a Chinese neolithic culture

Anderson D

I propose to take you on a journey, which started in 2000, when I bought my first Hongshan jade carving, a reproductive piece, in Hong Kong. Since then, as my collection and my obsession have grown at very low financial cost, I have been trying to fathom out why so many ‘experts’ are completely wrong about jade, and especially Neolithic jade. This corner of collecting is truly in the dark ages, where expert opinion rules over evidence, and this is providing me with t...