Endocrine Abstracts

Mullerian Inhibiting Substance (MIS) is a member of the transforming growth factor beta superfamily of growth factors, which causes regression of the Mullerian duct in male embryos, and is believed to act in a paracrine fashion after birth to regulate granulosa cell and oocyte function. MIS appears to be an important regulator of primordial follicle recruitment, and is also capable suppressing androgen production. Abnormal ovarian function is implicit in polycystic ovary syndr...

Insulin resistance and/or hyperinsulinemia are risk factors for CVD. Plasma homocysteine is also important risk factor for the development of premature cardiovascular disease (CVD) in type 2 diabetes. The relationship between level of insulin and homocysteine in insulin resistant state is not clear. The aim of our study was to investigate whether plasma homocystein levels are changed by acute hyperinsulinemia and to associate the change of plasma homocysteine with the level of...

Different hypothesis exist about the mechanism of glycose control after bariatric surgery involving intestinal bypass. The aim of our study was to determine the insulin and C-peptide response after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5 days after gastric by pass surgery. Glycaemia (mmol/l; glucose oxidase), insulin (ECLIA, Roche Diagnostics, pmol/l) and C-peptide (ECLIA, Roche Diagnostics, pmol/l) were det...

Introduction: It is known that many metals can contribute to thyroid dysfunction. Mercury (Hg) has attracted the attention of researchers because it is widespread in the environment (food, air, soil). However, only several studies deal with the exposure to low doses of Hg, which may reflect the real exposure of the general population.Aim: This study examined the relationship between measured concentrations of Hg in the blood and levels of free thyroxine ...

Introduction: Pheochromocytoma is a rare catecholamine-secreting tumor that arises from the chromaffin tissue of the adrenal medulla. Of the reported cases, only 10% consist in bilateral lesions and the probability of multiple endocrine neoplasia should always be investigated.Clinical case: Female patient, 19 years old, presented with a clinical history with 2 years of evolution, characterized by episodes of palpitations, headache, nausea and abdominal d...

Introduction: Adiponectin and its receptors are expressed in human osteoblasts, suggesting that adiponectin may be a hormone linking bone and fat metabolism. In contrast to adiponectin anabolic effect on bone in vitro studies, clinical and animal studies suggest that adiponectin may have negative effects on bone by stimulating the receptor activator of nuclear factor-κB ligand (RANKL) pathway and inhibiting the production of the decoy receptor for RANKL and osteopr...

Introduction: It is known that diabetes mellitus and its complex yet insufficiently known mechanisms affect bone strength and increases the fracture risk.Objective: The aim of this study was to assess bone mass measured by lumbar spine and hip DXA, in patients suffering from diabetes mellitus according to sex and type of diabetes.Material and methods: It was a prospective study. Included 150 diabetic patients of both sexes.<p c...

Background: Increased prevalence of abnormal aminotransferase levels and/or ultrasonographic evidence of hepatic steatosis have been found in women with polycystic ovary syndrome (PCOS), being more pronounced in overweight and obese patients. However, few data exist concerning the prevalence of PCOS in premenopausal women with nonalcoholic fatty liver disease (NAFLD).Objective: To investigate the presence of PCOS in overweight and obese premenopausal wom...

Introduction: Recent animal’s studies suggest that osteocalcin have influence on beta cell proliferation, insulin secretion and insulin sensitivity. Osteoblasts appear to regulate energy expenditure by acting on adipocytes and pancreatic islet cells via osteocalcin, a 49-residue polypeptide. In turn, adipose tissue may also influence bone remodeling by regulating the activity of osteoblasts through adipokines, including leptin and adiponectin. Some of the complex mechanis...

AZP-3601, a long-acting PTH/PTHrP(1-36) analog, is a candidate new treatment option for hypoparathyroidism (HP). As compared to conventional PTH(1-34), AZP-3601 binds with higher affinity to the R0 conformation of the PTH-1 receptor, resulting in prolonged signaling and sustained elevations in blood calcium (Ca++) in vivo, despite a very short circulating half-life. We assessed whether repeated injection of AZP-3601 into TPTX rats at doses aimed to normalize serum C...