Endocrine Abstracts

Introduction: Pentraxin-3 (PTX3) is an acute-phase reactant that shares structural and functional homology with C-reactive protein (CRP). However, unlike CRP, which is synthesized mainly in the liver, PTX3 is produced at the site of inflammation. It has been suggested that PTX3 plays the same role in the periphery that CRP does in circulation. PTX3 may represent a rapid marker for local inflammation.Methods: Fifty three patients with stable coronary arte...

Background: The patomechanism of developing ischemic heart disease (i.h.d.) is stenosis of coronary blood vessels with plaque placed on vascular endothelium built with monocytes/macrophages, foam cells, oxidized LDL, leukocytes, platelets and collagen. Atherosclerotic lesions are heavily infiltrated by cellular components associated with inflammation and influenced by other inflammatory factors. Trimetazidine, a clinically effective antianginal agent acts by optimizing cardiac...

Introduction: Vitamin D has pleiotropic effect on human body. Several studies showed that vitamin D deficiency has an influence on inflammation status in endocrine diseases (PCO-S, Graves disease, autoimmune endocrine disorders) and could reflect body fat tissue contain. Both, resistin and leptin, show pro-inflammatory effect.Aim: The aim of the study was to asses resistin and leptin serum concentration and its relationship with 25-OH vitamin D concentra...

Introduction: Interferon alpha (IFN alpha) is a cytokine with pleiotropic effects and via different pathways influences secretion of certain cytokines and hormones. Growth Hormone (GH) secreted from the pituitary has its physiological effects on various target tissues. The question is how IFN alpha administered in various type of diseases influences GH secretion. This study investigated acute effect of IFN-alpha on GH mRNA expression in rat anterior pituitary<p class="abst...

Cytokines play a role in cardiovascular diseases by inducing inflammation, cell proliferation and apoptosis. It is well known that activated macrophages are one of the main sources of inflammatory cytokines. Previous studies have shown that the cells found in the vascular wall produce various kind of cytokines which are involved in cardiovascular diseases. It has been reported that some cytokines (IL-6, IL-8) are increased in acute coronary syndrome. The results of some other ...

Introduction: There have been described that about 50% of women diagnosed with PCO-S, present lipid metabolism disorders, insulin resistance and incorrect blood pressure. They suffer not only from fertility disorders, but also present a risk of metabolic complications such as: obesity, type 2 diabetes and hypertension, which increase diet-related cancers and cardiovascular risk.Aim: To explore if serum omentin concentration could be an indicator of cardi...