Searchable abstracts of presentations at key conferences in endocrinology

ea0003p195 | Neuroendocrinology | BES2002

Weight gain and obesity in patients with hypothalamic damage

Daousi C , MacFarlane I , Pinkney J

Background: Weight gain is underrecognised in patients with hypothalamic damage and the prevalence and mechanisms are poorly defined. The aim of this study was to define the diagnoses and endocrine characteristics associated with weight gain.Subjects and methods: A retrospective study of 48 patients (25 female) mean (SD) age 45.3yrs (9.8).They included 22 patients with primary hypothalamic lesions (craniopharyngiomas, Rathke's cysts and other tumours)[g...

ea0095oc6.5 | Oral Communications 6 | BSPED2023

Growth hormone excess in children with pituitary adenomas associated with endocrine syndromes

Park Julie , Daousi Christina , Blair Joanne

Growth hormone (GH) excess is extremely rare in children. It can be associated with endocrine syndromes including MEN1, Carney complex and Mc Cune Albright syndrome. We describe two cases of GH excess and their management. Patient A (15yr M) presented with fibrous dysplasia affecting his cranium and a large café-au-lait spot covering his right scapula. His height was 193cm (2.6 SDS) and BMI 29.6kg/m2(2.3SDS). His IGF1 was 84.1nmol/L (22.5 – 65.9) and GH did not suppr...

ea0021p272 | Pituitary | SFEBES2009

Obesity and cardiovascular risk factors in adult patients with acquired structural hypothalamic damage

Steele Caroline , MacFarlane Ian , Javadpour Mohsen , Daousi Christina

Background: Obesity is a common sequel to tumours of the hypothalamic region and their treatment. Weight gain occurs at a rate faster than any expected age-related increase and despite treated hormone deficiencies.Methods: Retrospective review of patients with hypothalamic-pituitary tumours attending a large neuroendocrine clinic in UK.Results: Initial review in 2002 had identified 42 adults with tumours causing hypothalamic damage...

ea0011p622 | Neuroendocrinology and behaviour | ECE2006

The influence of growth hormone replacement (GHR) in adults with GH deficiency (GHD) on body composition, basal metabolic rate, physical activity and ingestive behaviour

Deepak D , Daousi C , Wilding JP , Pinkney J , Macfarlane IA

Objectives: GHR in adults with GHD favourably effects body composition (reduces fat and increases lean body mass) although body weight usually remains unchanged. However the effect of GHR on ingestive behaviour and voluntary physical activity in adults has not been studied.Methods: We studied 10 hypopituitary adults (8 males, 2 females, mean age 49.7 years) with severe GHD (mean peak GH response to glucagon 3.26 mU/l, baseline IGF-1 level 14.5 nmol/L) be...

ea0062p50 | Poster Presentations | EU2019

Nature’s price for Cushing’s disease: A blind eye and a hole in the (pituitary) Middle

Sullivan Heather , Westall Sam , McNulty Sid , Furlong Niall , Gilkes Catherine , Daousi Christina , Narayanan Prakash

Case history: A 61 year old male with a background of diabetes mellitus Type 2 and congestive cardiac failure (CCF) was diagnosed with Cushing’s disease in 2014 following identification of severe osteoporosis through investigations for non-traumatic vertebral fractures causing paraplegia.Investigations: He had high ACTH and cortisol levels which failed to suppress on low and high dose dexamethasone suppression tests, hypogonadotrophic hypogonadism a...

ea0059ep53 | Clinical practice, governance & case reports | SFEBES2018

Case Report: The experience of using Etomidate in the management of severe Cushing’s disease and MRSA bacteraemia in a district general hospital in the United Kingdom

Wong Stephanie , Yap Yew Wen , Narayanan Prakash , Daousi Christina , Al-Jubouri Mohammad , Mahgoub Yahya

Background: The management of Cushing’s disease can be challenging especially when patients can present with sepsis and severely immunocompromised with limited oral medications to achieve cortisol control. We review a case of Cushing’s disease and the medical management of Cushing’s disease.Case Report: A 54 year old female presented with symptomatic hyperglycaemia with truncal obesity, proximal muscle weakness, right posterior thorax haem...

ea0028p29 | Clinical biochemistry | SFEBES2012

The incidence, and impact on outcome, of hypo- and hypernatraemia in patients with spontaneous aneurysmal subarachnoid haemorrhage (SAH)

Daousi Christina , Gill Geoffrey , Cooper Shirley , Stoneley Catherine , Eldridge Paul , Javadpour Mohsen , Cuthbertson Daniel

Aims: To ascertain the incidence of hypo- and hyper-natraemia in patients admitted to a tertiary neurosurgical centre with confirmed spontaneous aneurysmal subarachnoid haemorrhage (SAH), and to determine their impact on length of hospital stay and mortality.Methods: Retrospective case note review of patients admitted between January 2008 and April 2011.Results: 402 patients with SAH were identified [mean (±sd</sma...

ea0028p254 | Pituitary | SFEBES2012

The Pituitary Apoplexy Score (PAS) in the evaluation and management of acute pituitary apoplexy: a single centre experience from the United Kingdom

Thondam Sravan , Bujawansa Sumudu , Noonan Carmel , MacFarlane Ian , Javadpour Mohsen , Daousi Christina

Aims: The United Kingdom (UK) guidelines for management of acute pituitary apoplexy recommend the Pituitary Apoplexy Score (PAS) to objectively assess clinical severity of this rare neuro-endocrine emergency. We aimed to apply retrospectively this scoring tool to a large, single centre series of patients with acute pituitary apoplexy, and to determine its applicability in the management of these patients in the acute setting.Methods: Retrospective study ...

ea0025p150 | Diabetes, metabolism and cardiovascular | SFEBES2011

The prevalence of non alcoholic fatty liver disease in GH deficiency and the effect of GH replacement

Gardner Chris , Irwin Andrew , Joseph Francis , Wong Chris , Adams Val , Daousi Christina , Kemp Graham , Cuthbertson Daniel

Background: Non-alcoholic fatty liver disease (NAFLD) is reported to be more prevalent in patients with GH deficiency (GHD) than in the general population. Case control studies have not however been undertaken. Recognition of NAFLD is important due to its association with cardiovascular disease and chronic liver disease.Aims: To determine i) the prevalence of NAFLD in patients with severe GHD compared to age and BMI-matched controls, and, ii) the effect ...

ea0023oc4.3 | Oral Communications 4 | BSPED2009

Pituitary adenomas presenting in children and young people: a single centre experience

Steele Caroline , Blair Jo , Didi Mo , Javadpour Mohsen , MacFarlane Ian , Daousi Christina

Introduction: Pituitary adenomas are uncommon in childhood and adolescence and knowledge of long-term outcomes is sparse. We describe a large cohort of patients, now attending our adult clinic.Patients and methods: Retrospective review of patients aged ≤18 years at diagnosis of a pituitary adenoma.Results: There were 24 patients (18 female), mean age at diagnosis 15.6 (range 11–18) years, current age 25.5 (14–47). O...