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The prevalence of obesity and its association with many health complications have evoked a high interest in adipose tissue metabolism. In man, glucocorticoid (GC) excess increases fat mass and the risk of developing Metabolic Syndrome. The enzyme responsible for modifying intracellular GC concentrations in adipose tissue is 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The aim of this study was to characterise the novel human preadipocyte cell line (Chub-S7) an...

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ea0016p521 | Obesity | ECE2008

Expression of adrenergic receptors and atrial natriuretic peptide in human adipose tissue of severe obese women and Rosiglitazone action during differentiation of human pre-adipocytes

Garruti Gabriella , Giusti Vittorio , Nussberger Jurg , Darimont Christian , Appert-Collin Aline , Perrini Sebastiano , NennigerTosato Monique , Giorgino Riccardo , Giorgino Francesco , Cotecchia Susanna

Background: The balance between Adrenergic Receptor (AR) subtypes and Atrial Natriuretic Peptide (ANP) is crucial for lipolysis. It was previously demonstrated that ANP is strongly lipolytic and we recently demonstrated that ANP is expressed and secreted by human pre-adipocytes. In previous studies, β-receptor density and lipolysis were higher in human visceral adipose tissue (HVAT) as compared with human subcutaneous adipose tissue (HSAT).Aims and ...

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Endocrine Abstracts

11beta-hydroxysteroid dehydrogenase is an early and essential marker of human adipogenesis

Expression of adrenergic receptors and atrial natriuretic peptide in human adipose tissue of severe obese women and Rosiglitazone action during differentiation of human pre-adipocytes

BiosciAbstracts