Endocrine Abstracts

In the UK, over 95% of children age 0–16 years presenting with diabetes have type 1 diabetes. Up to 25% of these present with DKA. Many present initially to GPs and it is important that children with symptoms of diabetes are referred urgently to Paediatric Diabetes Team.Aim: We carried out a survey of the current practise of GP’s when they suspect DM in a young person. The aim was to investigate whether they recognised the need for urgent refer...

Primary adrenal lymphoma is a rare cause of adrenal insufficiency, accounting for only approximately 1% of non-Hodgkin lymphoma cases. Most common subtype of PAL is diffuse large B cell lymphoma. A 71-year-old gentleman with the past history of hypertension, type 2 DM and the incidental finding of adrenal hyperplasia, presented with the general ill health with lethargy, weight loss and reduced appetite. He has the past history of hypertension, type 2 DM and the incidental find...

Objectives: To audit the endocrine referrals from a High Secure Hospital (HSH) to a department of endocrinology.Methods: During the study, the HSH had approximately 400 beds, 75% male, 75% mental illness (mostly schizophrenia), 25% psychopathic personality disorders. The average length of stay in the HSH was 8 years, the majority of patients receive antipsychotic drugs (APD) and obesity and cigarette smoking is common.Results: Over...

Several studies suggest that mortality rates due to cardiovascular disease (CVD) are increased in patients with hypopituitarism. We retrospectively assessed the prevalence of known diabetes, treated hypertension and dyslipidemia, known risk factors for cardiovascular disease (CVD), in a large population (n:250) of patients with hypothalamic-pituitary disease. We then prospectively screened 90 such patients for the following CVD risk factors: obesity, diabetes mellitus, smoking...

A 53 year old woman developed a firm thyroid mass which was removed. The histology of the thyroid mass showed auto-immune thyroiditis and Langerhans cell Histiocytosis ( LCH). She also complained of thirst and polyuria. A water deprivation test confirmed cranial diabetes inspidus (CDI) ,the symptoms of which resolved on DDAVP . A glucagon stimulation test showed a blunted growth hormone (GH) response of 13.3 milliU per litre with an IGF-1 level of 16 nanomol per litre. The cor...

Objective: To evaluate the effectiveness of low frequency pulsed electro magnetic field (LF-PEMF) in the management of diabetic peripheral neuropathy (DPN) symptoms.Methods: A comparative observational study of 60 patients, male and female (1:1) aged 60–85 years. Enrolment criteria – known diabetics, HbA1c 7–9 and DPN of 1–5 years. Patients were randomized into 2 treatment groups G1 and G2. The study period was 4 weeks (w) with result...

Objective: To evaluate the effectiveness of low frequency pulsed electro magnetic field (LF-PEMF) in the management of diabetic peripheral neuropathy (DPN) symptoms.Methods: A comparative observational study of 60 patients, male and female (1:1) aged 60–85 years. Enrolment criteria – known diabetics, HbA1c 7–9 and DPN of 1–5 years. Patients were randomized into 2 treatment groups G1 and G2. The study period was 4 weeks (w) with result...

Objective: To evaluate the effectiveness and compliance to L-thyroxine in the treatment of Hypothyroidism in a weekly dose of 7 times of normal dose as an alternative to daily dosing in young and middle aged adults.Methods: A randomized prospective observational study on 180 patients (female:male) ratio of 5:1 aged between 18 and 55 years with an established diagnosis of Hypothyroidism were assigned a weekly dose of seven times of normal dose. The patien...

Introduction: Serum C Peptide is traditionally used to diagnose factitious Hypoglycaemia due to exogenous Insulin. However in our case we were able to initiate child protection work up on the basis of skin marks which were noted during child’s admission in hospital.Case report: 2-year-old male presented with 3 days history of diarrhoea and vomiting. Past history and examination were unremarkable. Mother had gestational diabetes and was on insulin du...

Objectives: Prolactinomas can extend out of the sella turcica and invade surrounding structures and the brain. The prevalence and natural history of epilepsy at presentation of macroprolactinoma is not clear.Methods: The case records of 62 patients (34 male) with macroprolactinoma attending a neuroendocrine clinic were studied.Results: Four patients (6.5%, 3 males) had experienced epileptic seizures before the diagnosis of macropro...