Searchable abstracts of presentations at key conferences in endocrinology

ea0014p417 | (1) | ECE2007

Is there any relationship between the BsmI polymorphism in the vitamin D receptor gene and the occurrence of glucocorticoid-induced osteoporosis in asthmatic patients with long-term glucocorticoid treatment?

Tworowska Urszula , Bidzinska-Speichert Bozena , Obojski Andrzej , Demissie Marek , Slezak Ryszard , Lenarcik Agnieszka , Milewicz Andrzej

Introduction: Results of many studies indicate that BsmI polymorphism in VDR gene may influence bone tissue metabolism and may be useful in identifying patients at greater risk of glucocorticoid-induced osteoporosis.Aim of the study: To determine frequency of polymorphic variants of VDR gene (BsmI) and its relationship to phenotypic features characterizing bone status (BMD and metabolic bone turnover).Material and methods: Followin...

ea0011p8 | Bone | ECE2006

Is there any combined influence of the N363S polymorphism in the glucocorticoid receptor gene and the BsmI polymorphism in the vitamin D receptor gene on the occurrence of glucocorticoid-induced osteoporosis in patients with bronchial asthma?

Tworowska U , Bidzinska-Speichert B , Obojski A , Demissie M , Koper JW , Slezak R

Osteoporosis has a strong genetic component and is a common side-effect in patients with long-term glucocorticoid (GC) treatment. Vitamin D plays an important role in bone metabolism, and polymorphisms in its receptor (VDR) gene have been implicated in the pathogenesis of osteoporosis. On the other hand, variability in the sensitivity to GCs, due to polymorphic variants of the glucocorticoid receptor (GR) gene was observed in patients treated with GCs, both with regard to the ...

ea0011p291 | Diabetes, metabolism and cardiovascular | ECE2006

Pro12Ala PPAR gamma2 gene polymorphism in PCOS women - the role of the satiety and insulin activity regulating compounds

Bidzinska-Speichert B , Tworowska U , Demissie M , Bednarek-Tupikowska G , Slezak R

Peroxisome proliferator-activated receptors (PPARs) regulate adipocyte differentiation and gene expression by an interplay with other transcription factors. They are the nuclear receptor that are mostly expressed in adipocytes and some nonadipose tissues like intestinal wall, muscles, liver and macrophages. The aim of the study was to assess the possible association between Pro12Ala PPAR-gamma2 receptor gene polymorphism and satiety factors, insulin resistance and androgen exc...