Searchable abstracts of presentations at key conferences in endocrinology

ea0011p749 | Steroids | ECE2006

Hydrocortisone replacement therapy- the controversy continues…

Freel M , Thomson A , Devers M , Campbell K , Grant D , Wallace M , Connell J

Although hydrocortisone is the standard replacement therapy for primary or secondary adrenal insufficiency (AI), there are limited data on dosage requirements and the value of salivary monitoring in this patient group. We assessed inter-individual variability in cortisol metabolism and relationships between plasma and salivary cortisol profiles in 27 patients. Ten (3 male) patients had primary AI and 17 (8 male) secondary AI. Salivary and plasma cortisol levels were measured a...

ea0008p87 | Steroids | SFE2004

Variability in Hydrocortisone Pharmacokinetics Following Intravenous and Oral Administration in Patients with Adrenal Insufficiency

Devers MC , Thomson AH , Freel M , Grant D , Campbell K , Wallace M , Connell JMC

Hydrocortisone is the standard replacement therapy in patients with primary or secondary adrenal insufficiency (AI) but there is no current consensus on the most appropriate replacement dose and the extent to which this varies between individuals. This study examines inter-individual variability in cortisol metabolism in patients taking hydrocortisone therapy and investigates the relationship between plasma and salivary concentrations.Subjects and Method...