Endocrine Abstracts

Purpose: 111In-octreotide scinti aphy may be useful in patients with insulinoma during pre-surgical localization of the tumor and octreotide is effective in inhibiting insulin secretion and reducing the hypoglycemic events. The aim of the study was to evaluate 111in-octreotide scintigraphy in localizing primary and metastatic insulinomas and predicting the response to octreotide administration.Patients and methods: Diagnosis of insulinoma was made in 17 ...

Background: Levothyroxine is the standard treatment for central hypothyroidism (CH). Studies assessing the optimal dose are limited and include subjects with other untreated pituitary hormone deficits, affecting the interpretation of results. A reliable comparison with the dose used in primary hypothyroidism (PH) has not been reported.Aims: To evaluate daily and body-weight-adapted levothyroxine dose (BWA-dose) in a cohort of patients with CH on appropri...

Background: Cabergoline is effective in achieving normoprolactinaemia and tumour shrinkage in about 70% of patients with macroprolactinoma. Only a few studies have followed-up the adenoma shrinkage for periods >2 years;the need for continuing imaging thereafter is not certain.Aim: To evaluate tumour volume changes in patients with macroprolactinoma responsive to cabergoline during a long follow-up period.Patients and methods: M...

We report a case of a 53 years old woman who presented asthenia, cramps, cutaneous hyperpigmentation, nausea, vomiting, vague and non-specific epigastric abdominal pain, weight loss and hypotension. She was diagnosed with Addison’s disease because biochemical data were indicative for autoimmune adrenal failure (positivity for adrenal cortex antibodies). Nevertheless during the following 9 years the patient began to note the progressive reduction of pubic and axillary hair...

Objective: Acromegaly is a rare pituitary disease due to excessive secretion of GH. Insulin resistance, impaired glucose tolerance (IGT) and diabetes mellitus (DM) are common features in acromegaly. Seventy-four active acromegalic patients were retrospectively evaluated in order to determine the impact of family history for diabetes mellitus on glucose tolerance, insulin resistance and beta-cell function.Patients and methods: We studied 74 patients with ...