Searchable abstracts of presentations at key conferences in endocrinology

ea0034se1.2 | (1) | SFEBES2014

1776: revolution in liverpool: Matthew Dobson discovers hyperglycaemia

Macfarlane Ian

Mattew Dobson (1735–1784) was a Liverpool physician who was recognised with FRS for his numerous and varied publications. He investigated a patient with diabetes, which at the time was considered to be a kidney disorder, associated with excessive sweet tasting urine. His experiments showed that the sweet urine, on evaporation, contained white granular material indistinguishable from sugar. However, he also made the crucial observation that the blood serum was also sweet t...

ea0034p277 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Proliferative retinopathy in pregnancy after bariatric surgery

Dobson Helen , Raj Chitra , Munir Alia

Worsening of retinopathy after bariatric surgery has been reported1 and there has been a recent small cohort stating the same2, however to our knowledge this is the first report of occurrence in pregnancy post bariatric surgery with a previous diagnosis of type 2 diabetes mellitus.A 33-year-old female presented to the joint antenatal clinic at 28/40 gestation for a GTT.She had undergone a Roux en y gastric byp...

ea0013s34 | Animal disease, paradigm for human conditions | SFEBES2007

Stress and sex on the farm – lessons for humans

Dobson Hilary , Walker Susan , Ghuman Sarvpreet , Smith Robert

Research in farm animals has long been a cornerstone of our understanding of reproduction and holds similar opportunities for understanding mechanisms by which stress affects fertility. Sheep and cow experimental models are appropriate to humans, especially as detailed longitudinal studies are possible because of size and access to ovaries.Failure to realise genetic potential is a better definition of stress than ‘an increase in corticoids’; ma...

ea0034p45 | Clinical biochemistry | SFEBES2014

Serum 5HIAA: a better biomarker than urine for detecting and monitoring neuroendocrine tumours?

Adaway Joanne , Dobson Rebecca , Walsh Jennifer , Cuthbertson Daniel , Monaghan Philip , Valle Juan , Devlin Neil , Keevil Brian

Background: 5-hydroxyindole acetic acid (5-HIAA) (a metabolite of serotonin) is used as a marker for patients with serotonin-secreting neuroendocrine tumours. Currently, most laboratories measure 24 h 5-HIAA excretion in urine samples. Urine collections are cumbersome for the patient and impact on their daily activities; they are consequently often poorly performed, leading to over- or under-collection of urine and inaccurate 5-HIAA excretion results. Furthermore, large volume...

ea0019p21 | Bone | SFEBES2009

Activation of AMP-activated protein kinase represses chondrocyte proliferation

Dobson Pauline , Collins John , El-Mastry Omar , Goldring Mary , Brown Barry

AMP-activated protein kinase (AMPK) acts as a sensor and regulator of cellular energy homeostasis. Once activated, AMPK influences a number of responses including inhibition of anabolic pathways and the switching-on of catabolic pathways. Regulation of AMPK, which responds to an increase in the AMP/ATP ratio, could have an important role in chondrocyte function particularly in response to hormones and to stress such as occurs in osteoarthritis. Therefore, we sought to investig...

ea0007p118 | Endocrine tumours and neoplasia | BES2004

Expression and localisation of BAD and Akt in human breast cancer cell lines pre- and post-irradiation

Al-Bazz Y , Corke K , Dobson P , Underwood J , Brown B

The effects of radiotherapy, one of the main options currently available for cancer therapy, depend on various factors, including the dose and the radiosensitivity of tumour cells. Radiotherapy is known to induce apoptosis in breast cancer cells, but the effects of irradiation on components of the intracellular pathways involved in apoptosis and survival are largely unknown. BAD, which is a pro-apoptotic member of the Bcl-2 family plays a central role in the interaction betwee...

ea0011p379 | Diabetes, metabolism and cardiovascular | ECE2006

Chromosome 1p shows significant linkage to steroid metabolism in hypertension in the British Genetics of Hypertension Study

Padmanabhan S , Fraser R , Ingram M , Davies E , Munroe PB , Dobson R , Brown M , Samani N , Clayton D , Farrall M , Webster J , Lathop M , Caulfield M , Dominczak AF , Connell JM

Background: Glucorticoids can affect blood pressure in humans, as demonstrated most strikingly in Cushing’s syndrome. We have previously reported that total cortisol metabolite excretion is raised in obese subjects, while other investigations have identified genetically determined changes in glucocorticoid receptor function as contributors to hypertension. Furthermore, in essential hypertension, vasoconstrictor sensitivity to glucocorticoids is increased. Such raised sens...

ea0096p23 | Section | UKINETS2023

Reasons patients with carcinoid heart disease are deemed unfit for surgery: our tertiary centre experience

Douglas Sasha , Naneishvili Tamara , Yuan Mengshi , Muneeb Arshad Muhammad , Steeds Richard P

Introduction: Carcinoid heart disease (CHD) is a rare complication of neuroendocrine tumours (NETs) and carcinoid syndrome (CS). Approximately one in five patients with CS go on to develop CHD, which primarily affects the right side of the heart; leading to thickened, retracted, immobile and regurgitant cardiac valves that ultimately result in right ventricular (RV) dilatation and dysfunction 1 . Patients are referred for valve replacement if they have severe ...