Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep892 | Neuroendocrinology | ECE2017

Pituitary stalk lesions - experience of single center

Doknic Mirjana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Petakov Milan

Introduction: Lesions of the pituitary stalk (PSL) are a challenging diagnostic problem for clinicians. Because of the critical location and role of the pituitary stalk, mass lesions in this area are not often biopsied, and the diagnosis may be based on clinical evaluation and imaging. Due to biopsy risk, about 40% PSL diagnosis are ‘probable’ or ‘unknown’.The main clinical symptoms of PSL are visual field defect, DI and hypopituitarism.<p class="abstex...

ea0035p851 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

What is in the sella while spying on cancer? The role of FDG–PET/CT in differential diagnosis of sellar mass during staging for malignant disease

Miljic Dragana , Pekic Sandra , Doknic Mirjana , Stojanovic Marko , Popovic Vera

Positron emission combined with computed tomography using 18F-deoxy-glucose (FDG–PET/CT) is increasingly used in the staging and detection of malignant disease. Normal pituitary is not visualized by routine FDG–PET/CT and its radiological evaluation relies predominantly on magnetic resonance imaging (MRI). The role of FDG–PET/CT in differential diagnosis of sellar mass, in patients investigated for malignant disease, will be discussed.<p class="ab...

ea0032p897 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Serum GH but not IGF1 levels correlate with body composition parameters in both men and women with active acromegaly

Stojanovic Marko , Miljic Dragana , Pekic Sandra , Doknic Mirjana , Popovic Vera

Introduction: Generously supported by IPSEN)-->Active acromegaly is reported to be associated with considerable body composition changes, with significant lean body mass changes found only in men.Patients and methods: In patients with active acromegaly (n=40) 24 females and 16 males, 48.9±6.4 years old, with BMI of 28.04±1.27 kg/m2, diagnosed 4.15±1.09 years ago, body composit...

ea0032p942 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Clinical characteristics of patients with congenital hypopituitarism in advanced age

Doknic Mirjana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Popovic Vera

Background: Generously supported by IPSEN)-->Hypopituitarism is considered to be a risk factor for cardiovascular disease and early death in humans. However, some studies showed that most patients with isolated GH deficiency or combined pituitary hormonal deficiency due to gene mutations (PROP 1, GH receptors gene, GH-1 gene) can survive to advanced age.Aim: To collect clinical data on patients with congenital ...

ea0063p481 | Calcium and Bone 2 | ECE2019

Calcitonin response to calcium infusion test in patients with primary hyperparathyroidism

Jemuovic Zvezdana , Djurovic Marina , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Doknic Mirjana , Muzurovic Emir , Petakov Milan

Introduction: Primary hyperparathyroidism (PHPT) is disorder of one or more parathyroid glands, characterized by inadequately increased PTH secretion, almost always followed by hypercalcemia. Calcitonin, secreted by parafollicular C-cells in thyroid gland, is hypocalcemic hormone which partly acts as physiological antagonist of PTH.Aim: To evaluate calcitonin response in calcium infusion test in patients with primary hyperparathyroidism.<p class="abs...

ea0049ep953 | Pituitary - Clinical | ECE2017

Impact of etiology, age and gender on onset and severity of hyponatremia in patients with hypopituitarism

Miljic Dragana , Pekic Sandra , Doknic Mirjana , Nikolic-Djurovic Marina , Stojanovic Marko , Popovic Vera , Petakov Milan

Hyponatremia can unmask hypopituitarism and secondary adrenal insufficiency due to potent non-osmotic stimulation of vasopressin release under stressful conditions. Patients and methods: In a retrospective study 25 patients (13f/12m, age 58.9±18.6 years) with hyponatremia (119.7±10.5 mmol/l) were identified among 260 in-patients treated for hypopituitarism in our department over a decade. Results: Hyponatremia was recorded in 9.6% of our patients. In 84% it was the k...

ea0044p161 | Neuroendocrinology and pituitary | SFEBES2016

Bone turnover is significantly increased in patients with active acromegaly while bone mineral density remains normal

Stojanovic Marko , Miljic Dragana , Pekic Sandra , Doknic Mirjana , Petakov Milan , Popovic Vera

Introduction: Skeletal complications are among most persistent and invalidating systemic impacts of acromegaly. Assessment of bone health in acromegaly by dual-X-ray absorptiometry (DXA) alone might be insufficient or even misleading.Patients and methods: Patients with acromegaly (n=170) were classified as active (n=104), operatively cured (n=34) or medically controlled (n=32). We excluded patients with metabolic bone ...

ea0041ep882 | Pituitary - Clinical | ECE2016

Metabolic state in ACTH insufficient & ACTH sufficient patients with hypopituitarism not treated for growth hormone deficiency (GHD): a comparative study

Miljic Dragana , Pekic Sandra , Doknic Mirjana , Stojanovic Marko , Petakov Milan , Popovic Vera

Background: Inadequate glucocorticoid (GC) replacement may be associated with overexposure to GC, which can adversely influence metabolic and cardio-vascular state of hypopituitary growth hormone deficient adult patients (A-GHD). In this study we compared metabolic profile of ACTH insufficient and sufficient patients in A-GHD not treated with GH.Patients and methods: A cohort of 260 patients (age 48.6±12 years and BMI 28.7±6.6 kg/m2)...

ea0038p324 | Pituitary | SFEBES2015

Metabolic state in ACTH insufficient and ACTH sufficient patients with hypopituitarism not treated for growth hormone deficiency (GHD): a comparative study

Miljic Dragana , Pekic Sandra , Doknic Mirjana , Stojanovic Marko , Petakov Milan , Popovic Vera

Background: Inadequate glucocorticoid (GC) replacement may be associated with overexposure to GC, which can adversely influence metabolic and cardio-vascular state of hypopituitary growth hormone deficient adult patients (A-GHD). In this study we compared metabolic profile of ACTH insufficient and sufficient patients in A-GHD not treated with GH.Patients and methods: A cohort of 260 patients (age 48.6±12 years and BMI 28.7±6.6 kg/m2)...

ea0037gp.21.04 | Pituitary – Diagnosis of Cushing's disease | ECE2015

Exaggerated and additive ACTH responses following the combined ghrelin+CRH test in patients with Cushing's disease

Miljic Dragana , Polovina Snezana , Doknic Mirjana , Pekic Sandra , Stojanovic Marko , Petakov Milan , Popovic Vera , Micic Dragan

Ghrelin is able to stimulate HPA axis in both humans and animals. Exaggerated ACTH and cortisol responses to ghrelin have been shown in patients with CD. Here we studied the role of ghrelin alone or in combination with CRH in the diagnosis of CD. In 21 CD patient (18 female, age 49.8±10.2 years, BMI 29.8±0.8 kg/m2, ten macroadenomas 11 microadenomas) we performed: i) ghrelin test (100 μg iv bolus) ii) CRH test (100 μg iv bolus) and iii) ghrelin+C...