Endocrine Abstracts

A 24-year-old woman complained about secondary amenorrhoea after stopping oral contraceptive whereas she wanted to be pregnant. Physical examination showed an android obesity with a non-progressive but major hirsutism. Endocrinological investigations eliminated pregnancy but revealed on different samples a high plasma testosterone level (from 2.15 to 2.77 ng/ml), in the tumoral range whereas DHEA-sulfate, delta4-androstendione, sex binding protein and prolactine were normal. S...

We report a case of a 69-years-old woman who complained about progressive tachycardia, sweat and flush. Her single background was a breast cancer five years ago which was considered in remission. A first blood sample analysis showed an elevated rate of T4 whereas TSH was normal. An IgF1 assay was realised because of an acromegalic appearance and was abnormally high for sex and age. Further biological investigations confirmed central hyperthyroidism and acromegalia. Alpha subun...

Lipodystrophy is a rare disorder characterised by loss of adipose tissue, severe insulin resistance, diabetes, hypertriglyceridemia, hepatic steatosis with hypoleptinemia. Renal complications are also present but end stage renal disease is less frequent in partial lipodystrophy. We report efficacy and pharmacokinetics of metreleptine during hemodialysis in one case of partial lipodystrophy. A caucasian female presented with acute pancreatitis, major hypertriglyceridemia (25 g/...