Endocrine Abstracts

Aim of the study: to assess the interaction between TSH and the most common geriatric syndromes in the cohort of centenarians Materials and Methods: It was a longitudinal study, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and МOCA scores. We analyzed the interactions between TSH, m...

Aim of the study: To assess the most important metabolic factors in centenarians and their impact on mortality and prognosisMaterials and methods: Itwasalongitudinalstudy, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and MOCA scores. We also analyzed levels of HbA1c, cholesterol, LDL, H...

IntroductionMetformin and vildagliptin are the medications amongst first-line treatment options in type 2 diabetes patients. Few recent studies have explained positive pleotropic effects of metformin therapy by telomerase activation and telomeres length in leukocytes preservation. Knowing the primary role of insulin-signalling pathway in insulin resistance development and physiology of ageing, it is possible to suggest, that one of the protective mechani...

Aim of the study: To assess vitamin D levels in centenarians and its interaction with the most common geriatric syndromesMaterials and Methods: It was a longitudinal study, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and МOCA scores. QoL questionnaires were used as well. In all pat...

Objective: To investigate osteoporosis features in elder patients in Moscow populationMaterials and Methods: It was a retrospective study, during which we analyzed the data of 192 outpatients admitted to our Centre. In the focus of our attention was patients’ past medical history and T-criteria values assessed by DEXA-scan. The statistical analysis was performed using Prism 8 Version 8.0.1 (145). Statistically significant were differences with P...

Aim of the study: To investigate osteoporosis features in elder patients in Moscow population.Materials and Methods: It was a retrospective study, during which we analyzed the data of 192 outpatients (183 women and 9 men) admitted to Gerontology Research and Clinical Centre in 2018. In the focus of our attention was patients’ past medical history, such as any antiosteoporotic treatment received, vitamin D and Ca supplementations, any fractures in pr...

It is known that glucose disturbances contribute to vascular ageing. The length of telomere (TL) and telomerase activity (TA) are considered as biomarkers of cellular ageing. It is crucial to determine the role of telomere biology in different vessels changes in diabetic patients. The aim of our study was to determine the role of telomere biology in vascular ageing in patients with T2DM.Results: All patients were divided into two groups by the median of ...

Background: Network analysis of species abundance across different individuals suggested that the overall structure of the human gut microbiota in each individual conforms to discrete and distinct patterns defined by interactions within community members. This hypothesis was investigated using a dataset of metagenomic sequences from American, European and Japanese individuals. Multidimensional cluster analysis and principal component analysis revealed that all individual sampl...