Searchable abstracts of presentations at key conferences in endocrinology

ea0041s29.2 | New insights into the pathogenesis of PCOS | ECE2016

Energy balance and androgens

Duncan Colin

PCOS is associated with increased androgens, elevated insulin and obesity. As obesity and androgens promote insulin resistance and hyperinsulinemia increases ovarian androgen production, and the likelihood of obesity, the interaction between these factors is complex. We investigated the development of insulin resistance, hyperandrogenism and obesity using a clinically realistic ovine model of PCOS. Exposure of the pregnant ewe to increased testosterone from d62 to d102 of gest...

ea0031mte8 | (1) | SFEBES2013

Nanometre-resolution imaging of hormonal secretion in living cells in real time

Duncan Rory

Biochemists have defined a probably complete catalogue of proteins involved in insulin secretion. Similarly, over the last two decades, biochemists and physiologists have defined the physical characteristics of different types of ion channels that underlie normal pancreatic beta cell physiology. What is missing is information describing the ‘wheres and whens’: where are these proteins (i.e. not just for example on the surface of a cell, but how are the single protein...

ea0078OC9.2 | Oral Communications 9 | BSPED2021

Sex steroid priming for growth hormone stimulation testing – a systematic review

Duncan Gregor , Mitchell Rod

Background: Growth hormone stimulation testing (GHST) is used to diagnose growth hormone deficiency (GHD) in children. Given that sex steroids impact on anterior pituitary function, there is concern around the efficacy of GH stimulation testing in pre/peripubertal children, where sex steroid levels are low. Sex steroid priming prior to GH stimulation testing is thought to improve test efficacy in these children, however evidence to support its use in clinical practice is limit...

ea0086p68 | Metabolism, Obesity and Diabetes | SFEBES2022

The perils of steroids and salt in Covid-19 associated Diabetes

Biaye Abraham , Browne Duncan

Background: Following the RECOVERY study, dexamethasone is prescribed for patients requiring inpatient treatment of Covid. Cases of new and atypical diabetes have been reported during this pandemic. The risk of steroid induced hyperglycaemia is well recognised but other metabolic sequelae less so. We present a patient who developed severe hypernatraemia following commencement of dexamethasone.Case Report: A 44-year-old man (unvaccinated) was diagnosed wi...

ea0086p229 | Metabolism, Obesity and Diabetes | SFEBES2022

FreeStyle Libre 2 use in non-diabetes setting – A case of post-bariatric surgery dumping syndrome causing severe hypoglycaemia in pregnancy

Biaye Abraham , Browne Duncan

Flash glucose monitoring has increased dramatically in patients with diabetes since the introduction of the FreeStyle libre 2 (FSL) incorporating hypoglycaemia predictive features and an alarm system. A 31-year-old lady, gravida 2, para 1 presented at 26 weeks’ gestation following a car accident where she fractured clavicle and navicular. She reported blurred vision and subsequent collapse whilst driving (with her daughter as a passenger) prior to the accident. Paramedics...

ea0031apw1.1 | Digital copies: exploiting numerical models of biological systems | SFEBES2013

Modelling neuroendocrine systems

Leng Gareth , MacGregor Duncan

In recent years, the increasing availability of massive computational capacity has reached what may be seen as a ‘tipping point’, bringing once unimaginable computational power into the lab. This is enabling models to be built, fit and refined during experiments, making predictive models that are powerful tools for hypothesis generation and testing. Neuroendocrine systems are at the forefront of these advances. Because of the exceptional opportunities that they offer...

ea0028mte7 | (1) | SFEBES2012

Regulating periods and optimising fertility in PCOS

Duncan W Colin

Although polycystic ovary syndrome (PCOS) is arguably the commonest endocrine condition, affecting 7% of women, medical students and junior doctors often find it difficult to grasp its pathophysiology. This workshop describes a paradigm to teach about PCOS and uses this framework to describe lifestyle, hormonal and metabolic strategies for the regulation of periods and optimisation of fertility.Declaration of interest: There is no conflict of interest th...

ea0028p58 | Clinical practice/governance and case reports | SFEBES2012

Role of plasmapheresis in rapid pre-operative stabilisation of severe Grave’s thyrotoxicosis

Kankara ChenchiReddy , Browne Duncan

We describe the use of plasmapheresis for pre-operative stabilisation in a case of refractory Grave’s thyrotoxicosis. Our case is a 21 year woman with 12 month history of severe Grave’s disease. Her serum freeT4 was >100 pmol/L (ref.range 11–24) and TSH <0.014 mU/L at diagnosis, had no goitre and negative thyroid peroxidase antibodies. Thyroid uptake scan confirmed Grave’s disease. She was treated with carbimazole 60 mg daily and propranolol. She re...

ea0025s6.1 | Novel application of thyroid hormone analogues: thyroid hormones, thinking outside the capsule | SFEBES2011

Thyroid hormone action: genomic and non-genomic effects

Bassett J H Duncan

The classical genomic actions of triiodothyronine (T3) are mediated by high-affinity nuclear receptors that directly regulate gene expression. By contrast, the non-genomic effects of thyroid hormones occur rapidly and are unaffected by inhibitors of transcription and protein synthesis. The genomic actions of thyroid hormone have an established role in the development, differentiation and homeostatic maintenance of target tissues. The THRA and THRB gene...

ea0022s3.3 | Bone cell biology | ECE2010

The role of the hypothalamic–pituitary–thyroid axis in bone

Bassett J H Duncan

Disruption of the HPT-axis during growth profoundly influences skeletal development and effects may not be reversed fully following correction of thyroid status. Adult thyrotoxicosis leads to increased bone turnover and is an established risk factor for osteoporotic fracture. The conventional view that skeletal responses to abnormal thyroid status result solely from altered T3 action in bone has, however, been questioned by studies proposing TSH as a negative regula...