Endocrine Abstracts

Background: Transsphenoidal surgery (TSS) is the primary treatment of choice in acromegaly. Previous research succeeded to some extent in predicting remission after TSS. However, it was based mainly on clinical and radiological data, lacking histopathological evaluation.Objective: To produce a clinicopathological prediction model for remission after TSS for acromegaly, enabling clinicians to better inform patients on expected treatment outcome.<p cla...

Introduction: Congenital central hypothyroidism occurs either as isolated TSH deficiency or in conjunction with other pituitary hormone deficits. Undetected central hypothyroidism is associated with developmental delay in children and adverse cardiometabolic sequelae in adults. Hitherto, mutations in the TRH receptor (TRHR) or TSHβ subunit (TSHB) genes are the only known causes of isolated TSH deficiency.Methods: Using whole exome and candidate gene...

Introduction: Congenital central hypothyroidism occurs either as isolated TSH deficiency or in conjunction with other pituitary hormone deficits. Undetected central hypothyroidism is associated with developmental delay in children and adverse cardiometabolic sequelae in adults. Hitherto, mutations in the TRH receptor (TRHR) or TSHβ subunit (TSHB) genes are the only known causes of isolated TSH deficiency.Methods: Using whole exome and candidate gene...

Introduction: Papillary thyroid carcinoma (PTC) is the most frequent endocrine malignancy. Apart from genetics, autoimmunity has been implicated in its pathogenesis. In this context, we set out study the role of Pro- inflammatory cytokines in PTC in South Indian population.Material and methods: This prospective case-control study was conducted on surgically managed PTC patients. Institutional ethical committee approval was obtained. Diagnosis of PTC was ...

Introduction: Primary Hyperparathyroidism (PHPT) is a frequent endocrine disease which requires surgical excision for definitive cure. Apart from genetic role in its pathogenesis, there are conflicting reports about role of immunomodulation in literature. In this context, we set out study the role of Pro- inflammatory cytokines in PHPT in South Indian population.Material and methods: This prospective case-control study was conducted on surgically managed...

Introduction: Graves’ disease (GD) is one of the commonest organ specific autoimmune thyroid disease. Surgical thyroidectomy is one of the definitive treatment modalities. Autoimmunity has been implicated as one of the main cause of GD. In this context, we set out study the role of Pro- inflammatory cytokines in GD.Material and methods: This prospective case-control study was conducted on surgically managed GD patients. Institutional ethical committ...

Introduction: Hashimoto’s thyroiditis (HT) is one of the commonest organ specific autoimmune thyroid disease. Though it is mostly treated medically, certain goitrous forms require surgical thyroidectomy for various indications. Autoimmunity has been implicated as one of the main cause of HT. In this context, we set out study the role of Pro- inflammatory cytokines in HT.Material and methods: This prospective case-control study was conducted on surgi...

Introduction: Nodular thyroid disease (NTD) is one of the commonest endocrine disease with incidence ranging from 5–30% in various populations Worldwide. They often require surgery for indications such as pressure symptoms or size related reasons. The natural history and etiopathogenesis are largely unclear except in few endemic regions. Immunomodulatory role has often been implicated in their pathogenesis. In this context, we set out study the association between Pro- in...

Introduction: Papillary thyroid carcinoma (PTC) is the commonest endocrine malignancy. Apart from genetic role in its pathogenesis, autoimmunity has been implicated in certain papers. But, reports have been tripolar ranging from causative, protective and neutral role of immunomodulation. In this context, we set out study the role of Pro- inflammatory cytokines in PTC in South Indian population.Material and methods: This prospective case-control study was...

IntroductionPapillary thyroid carcinoma (PTC) is the most common endocrine malignancy. Apart from genetics, autoimmunity has been implicated in its pathogenesis. But, reports have been conflicting ranging from causative, protective and neutral role of immunomodulation. In this context, we set out study the role of Pro- inflammatory cytokines in PTC in South Indian population.Material and methodsThis pilot pro...