Endocrine Abstracts

Hypercalcemia is a rare pathology in pregnancy and postpartum, but an important one to recognize in the effort to reduce fetal and neonatal morbidity and mortality. We describe a case of hypercalcemia at end of pregnancy. A30 year-old woman was referred to Endocrine clinic at 36 weeks Gestations for symptomatic mild hypercalcemia (tired and lack of energy). She had previous history of acute lymphocytic leukemia treated with bone Marrow Transplant in remission for the last 6 ye...

New immune-modulatory therapies for malignancies have transformed their management with significantly enhanced survival outcomes. Pembrolizumab is an antibody against the programmed-death-1 molecule that increases the cytotoxic function of T-cells with excellent tumor response rates. Endocrinopathies including thyroiditis are an increasingly recognized side effect of this medication. We describe a unique a case where Thyroiditis occurred as a result of treatment with Pembroliz...

Hyponatraemia is the most commonly recorded electrolyte abnormality occurring in 7% to 8% of elderly, ambulatory patients and 15 to 20% of hospitalized patients presenting a variety of symptoms ranging from very mild to life threatening. Correction of hyponatremia has been shown to improve the symptoms and signs associated with this condition. It is also recognized that excessively rapid correction of hyponatremia can be detrimental. During hospital admission, hyponatremia is ...

Introduction: Adult Growth Hormone Deficiency (AGHD) is associated with osteoporosis. Underlying mechanisms involved in the pathogenesis include reduced target-organ sensitivity to the effect of PTH. Growth Hormone Replacement (GHR) in AGHD leads to increased PTH target-organ sensitivity and consequently increased bone turnover and bone mineral density (BMD).Aims: We determined the effect of alendronate, given in addition to GHR, on PTH target-organ sens...

Adult Growth Hormone Deficiency (AGHD) is associated with osteoporosis. PTH is secreted in a circadian rhythm and temporal fluctuations in PTH concentration, particularly at night, appear to be important in the regulation of bone turnover. Serum phosphate is an important determinant of PTH, with changes in phosphate preceding fluctuations in PTH concentration. We examined the difference in PTH and phosphate circadian rhythmicity in AGHD patients with normal and reduced bone mi...

Adult Growth Hormone Deficiency (AGHD) is associated with reduced bone mineral density (BMD) and bone turnover. Abnormalities in PTH circadian rhythmicity, including blunted nocturnal rise in PTH concentration have been reported in AGHD and may underlie the pathogenesis of osteoporosis. Serum phosphate is an important regulator of PTH, with changes in phosphate concentration preceding fluctuations in PTH. We examined the effect of oral phosphate therapy on PTH circadian rhythm...

Objective: Obesity is a major problem in pregnancy. Obesity has been associated with decreased vitamin D levels, diabetes and reproductive risks. Women were followed through pregnancy with frequent blood samples to determine any differences between lean and obese subjects. We present data on vitamin D levels through gestation in these subjects.Methods: Normal pregnant women at 6–9 weeks GA provided blood samples every 2 weeks and body weights were r...

Introduction: There is increasing evidence suggesting that adiponectin plays a role in the regulation of bone metabolism. We have studied the changes in the circulating concentration of adiponectin in lean and obese post-menopausal women with and without osteoporosis and its association with a marker of bone formation – type 1 procollagen amino-terminal pro-peptide (P1NP) and a marker of bone resorption – type 1 collagen C-telopeptide (βCTX).<p class="abstex...

Introduction: Strontium ranelate (SR) is a dual action bone agent that increases bone formation and reduces bone resorption. Previous long term studies with SR have demonstrated minimal reductions in parathyroid hormone (PTH) and adjusted calcium (ACa) levels with increase in phosphate (PO4) concentrations, but the exact mechanism of action of SR remains unclear. Postmenopausal women with low bone mineral density (BMD) have relatively high circulating PTH concentrat...

Introduction: The beneficial effect of GH replacement on bone in AGHD patients is mediated by improvements in target organ sensitivity to PTH and phosphocalcium metabolism. In aging women with established osteoporosis, GH and IGF-1 concentrations are lower and administration of GH has been shown to increase bone turnover and BMD, but the mechanisms remain unclear.Methods: Fourteen postmenopausal women (63.4±2.1 years; mean BMD T score ± ...