Endocrine Abstracts

Background: We have recently demonstrated that blood pressure (BP) in children was elevated in males compared to females in the post-pubertal period. We have also shown that the Y chromosome in associated to BP in adult men. Here we report on the effect of 2 polymorphisms on the Y chromosome on BP in male children studied longitudinally both in the pre- and post-pubertal periods.Methods: We genotyped for 2 SNPs (HindIII +/-; M9 C/G) on the Y chromosome n...

Introduction: Patients with arginine vasopressin deficiency (AVP-D), known as central diabetes insipidus (cDI), often report psychological symptoms such as heightened anxiety levels, difficulties describing emotions, and depressed mood despite adequate treatment with desmopressin. Given the anatomical proximity, disruptions of the hypothalamic-pituitary axis causing an AVP-D could also disturb the oxytocin (OXT) system. OXT regulates socio-emotional functioning, including fear...

Background: Studies in rodents and non-human primates revealed beneficial effects of oxytocin on systemic metabolism, body weight and food intake. Several rodent studies demonstrated that olfactory stimulation with D-limonene, improves systemic glycemia, reduces food intake and body weight, while olfactory stimulation with the scent of lavender oil had opposite effects. The aim of this study was to investigate if systemic oxytocin levels are affected upon olfactory stimulation...

The currently best known example of a commercialized theranostics is the combination of HercepTest and Herceptin wherein the former is used for HER2 expression assessment and selection of patients that might benefit from the treatment with the latter. However, HercepTest requires biopsy which is an invasive procedure, not sufficiently accurate, and very difficult to perform on several lesions and repeatedly in order to monitor the treatment response. While positron emission to...