Searchable abstracts of presentations at key conferences in endocrinology

ea0066pens1.3 | (1) | BSPED2019

Patients living with CAH

Elford Sue

Since my son was born (32 years ago) the monitoring and treatment for patients with CAH has improved considerable, with multidisciplinary teams providing excellent care from birth. It is still pretty scary for parents when they are given the diagnosis but they are able to access information on the condition, not just from their hospital team but also via support groups and the internet. Social media has enabled them to chat to other families online which can help them feel les...

ea0007p14 | Bone | BES2004

Adenosine stimulates IL-6 but inhibits osteoprotegerin secretion by osteoprogenitor cells

Evans B , Elford C , Ham J

Nucleotide receptors can be classified into two groups: P1 receptors where adenosine is the primary ligand, and P2 receptors where the main ligands are ATP, ADP, UTP and UDP. The presence of the P2 family members in osteoblasts and osteoclasts has been known for some time, but there have been no published studies on the role of adenosine in bone physiology.We have demonstrated the presence of the four P1 adenosine receptor subtypes (A1, A...

ea0017oc9 | Late effects | BSPED2008

Possible mechanisms for osteonecrosis during treatment for childhood acute lymphoblastic leukaemia: effects of chemotherapy and lipopolysaccharide on osteocytes

Abdussalam A , Elford C , Jenny MEM , Gregory JW , Evans BAJ

Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer. Given dramatic improvements in survival rate (>80%), long term quality of life is of rising concern. Skeletal complications including osteonecrosis (ON) are being reported more frequently, affecting up to 38% of children treated for ALL though the pathogenesis is unclear.The purpose of this study is to examine possible mechanisms causing ON. We hypothesize that polychemotherapy ...

ea0007p39 | Diabetes, metabolism and cardiovascular | BES2004

A randomised controlled trial of laser treatment among hirsute women with polycystic ovary syndrome

Clayton W , Lipton M , Sherr L , Rustin M , Elford J

Objective: To evaluate the impact of laser treatment on the severity of facial hirsutism as well as psychological morbidity in women with polycystic ovary syndrome (PCOS).Methods: Randomised controlled trial of 5 high fluence treatments (intervention) or 5 low fluence treatments (control) over 6 months. 88 women with facial hirsutism due to PCOS were recruited from hospital outpatient clinics and a patient support group in 2002. Main outcomes were self r...

ea0077p164 | Bone and Calcium | SFEBES2021

Resolution of primary hyperparathyroidism following parathyroid adenoma infarction on treatment with cinacalcet

Elford Jane , Head Simeon , Wood Ffion , Williams Elin , Tellier Genevieve , Kraus Alex , Wilton Anthony

Spontaneous resolution of primary hyperparathyroidism following infarction for parathyroid adenomas is rare with infarction on treatment with cinacalcet being even rarer. A 53 year old female who presented to primary care with malaise was found to have biochemical evidence of primary hyperparathyroidism with adjusted calcium 3.31 mmol/l and parathyroid hormone 28.8 pmol/l. Previous medical history was unremarkable. Following discussion with endocrinology, treatment with cinaca...

ea0015p16 | Bone | SFEBES2008

Adenosine is an important regulator of mesenchymal stem cell differentiation into osteoblasts

Gharibi Borzo , Lewis Barbara Mary , Elford Carole , Ham Jack , Evans Bronwen Alice James

Pluripotent mesenchymal stem cells (MSCs) have the capacity to differentiate into osteoblasts, adipocytes and chondrocytes and are characterised by expression of CD105, CD90 and CD73. CD73 is the enzyme that dephosphorylates AMP to adenosine. The role of adenosine in MSCs is unknown and we have thus investigated whether it plays a role in the differentiation process to osteoblasts.MSCs, obtained from the bone marrow of 10 week old male rats, were expande...

ea0011oc7 | Signal transduction OC1 Novartis Oncology Young Investigator Award | ECE2006

The effect of bone marrow stem cell (BMSC) differentiation on growth hormone receptor (GHR)-associated signalling pathways

Lewis MD , Easter TE , Elford C , Ludgate ME , Evans BAJ , Rees DA , Scanlon MF

GH has diverse direct effects including the induction of lipolysis in adipocytes and mineralisation in bone. Interestingly, pluripotent mesenchymal stem cells can be isolated and cultured from adult bone marrow and induced to differentiate in vitro to both adipocytes and osteoblasts. GHR activation can be coupled to JAK2/STAT5 and the ERK (MAPK) pathway. We have therefore studied the evolution of GHR-associated cell signalling in adult rat BMSC’s during differentia...

ea0013p165 | Diabetes, metabolism and cardiovascular | SFEBES2007

Bone marrow stem cells differentiating along the adipogenic lineage show marked up regulation of the adenosine A1 receptor transcript

Easter Tammy , Lewis B Mary , Elford Carole , Ludgate Marian , Ham Jack , Evans Bronwen , Scanlon Maurice , Lewis Mark

Bone marrow stem cells (BMSCs) are able to differentiate along multiple lineages including adipogenic and osteogenic lineages. The adenosine A1 receptor (A1R) modulates adipose tissue function causing an inhibition of lipolysis. We therefore studied A1R expression in BMSCs induced to differentiate along the adipogenic lineage.BMSCs were isolated from rat femur (10 wk male Wistar), cultured in control medium (alphaMEM 10% FCS) and then plated into adipocy...

ea0094p12 | Adrenal and Cardiovascular | SFEBES2023

Service evaluation suggests variation in clinical care provision in adults with congenital adrenal hyperplasia in the UK and Ireland

Madden Doyle Lauren , Faisal Ahmed Syed , Elford Sue , Elhassan Yasir , James Lynette , Lawrence Neil , Llahana Sofia , Rees Aled , Tomlinson Jeremy , O'Reilly Michael , Krone Nils

Background: The Congenital adrenal Hyperplasia (CAH) Adult Study Executive (CaHASE) identified poor metabolic outcomes and reduced quality of life in CAH. CaHASE2 was recently established to examine the current status of CAH care. We surveyed clinical practice in the UK and Ireland, and awareness and use of the International CAH (I-CAH) Registry.Methods: We undertook an anonymised online survey targeting clinicians provi...

ea0095p81 | Adrenal 2 | BSPED2023

National service evaluation of care for children and young people with congenital adrenal hyperplasia in the UK: Survey responses from patients and clinicians

Lawrence Neil , Bacila Irina , Ji Xiaochen , Faisal Ahmed S , Alvi Sabah , Bath Louise , Blair Jo , Cheetham Tim , Crowne Liz , Davies Justin H , Dattani Mehul , Gevers Evelien , Krone Ruth , Patel Leena , Thankamony Ajay , Randell Tabitha , Ryan Fiona , Elford Sue , Blackett Sallyann , Krone Nils

Aim: To quantify difference in service provision for children and young people (CYP) living with CAH across the UK.Methods: A national service evaluation using online questionnaires circulated to patients and clinicians from secondary and tertiary UK centres managing CYP with CAH, and via the ‘Living with CAH’ support group mailing list.Results: Total of 195 responses rel...