Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp48 | Acromegaly and GH | ECE2019

Prolonged diagnostic delay in acromegaly is associated with long-term morbidity and excess mortality: data from a nationwide study

Esposito Daniela , Ragnarsson Oskar , Johannsson Gudmundur , Olsson Daniel S

Background: Clinical features of acromegaly develop insidiously and the diagnosis is often delayed. However, diagnostic delay (DD) in acromegaly has not been systematically investigated. Our primary aim was to investigate DD in a nationwide cohort of patients with acromegaly. Secondary aim was to study the impact of DD on morbidity and mortality.Methods: Adult patients diagnosed with acromegaly between 2001 and 2013 were identified in the Swedish Nationa...

ea0070aep65 | Adrenal and Cardiovascular Endocrinology | ECE2020

Patients with adrenal insufficiency have cardiovascular features associated with hypovolemia

Esposito Daniela , Johannsson Gudmundur , Ragnarsson Oskar , Pasquali Daniela

Context: Patients with adrenal insufficiency (AI) have excess mortality and morbidity, mainly due to cardiovascular diseases. The mechanisms for this is unclear.Objective: To assess cardiovascular structure and function in AI patients on conventional replacement therapy and after switching to once-daily, modified-release hydrocortisone (OD-HC).Methods: The analysis included 17 adult AI patients (11 with primary AI, 7 with secondary...

ea0029p854 | Endocrine tumours and neoplasia | ICEECE2012

The high-mobility group A1-oestrogen receptor β nuclear interaction impairs in human testicular seminomas

Esposito F. , Boscia F. , Franco R. , Chieffi P.

It is well established that oestrogens participate in the control of normal spermatogenesis and endogenous or environmental oestrogens are involved in pathological germ cell proliferation including testicular germ cell tumours. The effects of oestrogen are now known to be mediated by oestrogen receptor-α (ERα) and ERβ subtypes, but only ERβ has been found in human germ cells of normal testis. However, its expression was markedly diminished in seminomas, emb...

ea0026p88 | Endocrine tumours and neoplasia | ECE2011

cAMP induces PATZ1 and estrogen receptor β nuclear re-localization in the human seminoma TCam-2 cell line

Boscia F , Esposito F , Kitazawa S , Looijenga L , Chieffi P

Estrogen exposure has been linked to a risk for the development of testicular germ cell cancers. The effects of estrogen are now known to be mediated by estrogen receptor α (ERα) and ERβ subtypes, but only ERβ has been found in human germ cells of normal testis. However, its expression was markedly diminished in seminomas, embryonal cell carcinomas, and in mixed germ cell tumours but remains high in teratomas. PATZ1 is a recently discovered zinc finger prot...

ea0022p663 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Sellar lesions in Ollier disease: case report and a review of the literature

Jaffrain-Rea Marie-Lise , Giangaspero Felice , Esposito Vincenzo , Cantore Giampaolo

Ollier disease (OD) is a rare disease, with multiple enchondromas localized in the metaphysis of long bones, hands and feet, developing in the first decade of life, with potential malignant transformation into chondrosarcomas. OD is usually sporadic and probably caused by post-zygotic genetic alterations leading to mosaicism. A PTH/PTHrP receptor type 1 (PTHR1) gene mutation is present in some cases.Case report: A 21-years old male patient was referred t...

ea0081p594 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Circulating levels of endothelial progenitor cells (EPCs) and sexual function in fertile women with type 1 diabetes

Maio Antonietta , Tomasuolo Maria , Porcellini Chiara , Sarnataro Annalisa , Pernice Vlenia , Castellano Laura , Caruso Paola , Esposito Katherine

Introduction: Female sexual dysfunctions (FSD) are complex conditions characterized by impairment of the female sexual cycle. Higher prevalence of FSD has been found in women with diabetes, as compared with matched healthy controls. Endothelial progenitor cells (EPCs) are circulating mononuclear cells participating in the neo-angiogenesis. There is evidence that circulating levels of EPCs are reduced in diabetic patients compared with age-matched subjects. The relationship bet...

ea0084op-03-12 | Oral Session 3: Advanced Thyroid Cancer | ETA2022

Clinicopathological and epidemiological features of thyroid cancer patients intended to initiate systemic therapy

Minaldi Elisa , Esposito Gerardo , Giani Carlotta , Valerio Laura , Agate Laura , Molinaro Eleonora , Elisei Rossella

Objectives: The majority of patients with differentiated thyroid carcinoma (TC) have an excellent prognosis, with a 5-year survival rate of 98.3%, and only rarely reaches an advanced stage of disease. The present study aims to identify the clinicopathological and epidemiological features at the time of diagnosis of a group of patients who required to be treated with systemic therapy with tyrosine-kinase inhibitors (TKI).Methods: We retrospectively evalua...

ea0063gp52 | Acromegaly and GH | ECE2019

Final height in childhood onset hypopituitarism

Esposito Andrea , Improda Nicola , Moracas Cristina , Barbieri Flavia , Alfano Sara , Capalbo Donatella , Salerno Mariacarolina

Background: Growth hormone (GH) deficiency(GHD) in childhood is associated with impairment in linear growth. GH therapy enables the achievement of normal adult height in most cases. The response is variable and factors influencing height outcome are still not clearly defined.Objective: To evaluate near adult height (NAH) in a single center cohort of childhood onset GHD patients treated with GH and investigate main predictors of final height (FH).<p c...

ea0063p684 | Pituitary and Neuroendocrinology 2 | ECE2019

Effects of growth hormone deficiency (ghd) and gh treatment on early markers of atherosclerosis in children

Barbieri Flavia , Improda Nicola , Esposito Andrea , Moracas Cristina , Gaeta Valeria , Salerno Mariacarolina

Background: Endothelial dysfunction is considered an early step in the development of atherosclerosis, while an increased intima-media thickness (IMT) represents one of the earliest morphological changes in the arterial wall in the process of atherogenesis. Only a few studies have investigated endothelial dysfunction and IMT in GHD children and results are still inconsistent.Objective: Aim of our study was to evaluate the effects of GHD and GH treatment ...

ea0049ep1293 | Thyroid (non-cancer) | ECE2017

TSH oscillations in young patients with type 1 diabetes may be due to glycemic variability

Bellastella Giuseppe , Casciano Ofelia , Scappaticcio Lorenzo , Giugliano Dario , Ida Maiorino Maria , Esposito Katherine

: A link between thyroid dysfunction and diabetes mellitus exist. Uncertainties on the role of glycemic variability on thyroid hormones and TSH concentrations still persist. We want to evaluate the influence of glycemic variability on thyroid hormones and TSH concentrations in patients with type 1 diabetes (T1DM). 77 patients with T1DM on insulin therapy without thyroid dysfunction and 100 healthy controls were evaluated for basal glucose concentrations, HbA1c, thyroid hormone...