Searchable abstracts of presentations at key conferences in endocrinology

ea0034p206 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Dark chocolate rich in polyphenols improves insulin sensitivity in the adult non-diabetic population

Farhat Grace

Polyphenols are chemical components found largely in plants. Dark chocolate (DC) is one of the highest sources of polyphenols in foods. Several animal and few human studies have suggested that DC might improve insulin sensitivity and decrease glucose levels. The aim of this study was to determine the effect of polyphenol-rich DC (PRDC) on insulin sensitivity (determined by HOMA and QUICKI) and fasting glucose levels. Sixty-one volunteers with no history of diabetes, hypertensi...

ea0035p170 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Polyphenol-rich dark chocolate lowers LDL oxidation without affecting high-sensitivity CRP levels in adults

Farhat Grace , Al-Dujaili Emad

Chronic inflammation and oxidative stress have been described as crucial factors in the pathogenesis of atherosclerosis and the occurrence of cardiovascular diseases (CVD). Polyphenols are phytochemicals with established antioxidant properties, and dark chocolate (DC), a highly consumed food, is one of main food sources of polyphenols. Many human studies have suggested a lowering effect of DC on oxidized LDL levels, while its impact on high sensitivity CRP (hs-CRP) -one of the...

ea0081p510 | Late-Breaking | ECE2022

Suppressor of cytokine signaling-3 in pregnant females with or without hypertension: a case-control study

Ali Huma , Ali Mubeen , Farhat Sabah , Sadia Fatima Syeda

Suppression of Cytokine Signalling-3 (SOCS-3) modulates the inflammatory pathways responsible for vascular stability by playing a role in inflammatory pathway. It acts by inhibiting the activation of Janus kinase-signal transducer and activating of transcription (JAK-STAT) pathway to transmit their information into the cell nucleus. Therefore, this study aimed to estimate SOCS-3 levels in 2 nd trimester pregnant females and correlate it with blood pressure. A case control stud...

ea0020p417 | Diabetes and Cardiovascular | ECE2009

Evaluation of the severity of hepatic steatosis in type 2 diabetes

Ben Salem Hachmi Leila , Ben Farhat Leila , Waghlani Ridha , Bouzid Chiraz , Hendaoui Lotfi , Ben Slama Claude

Objective: The objective of this study was to examine the factors influencing the severity of hepatic steatosis in type 2 diabetes.Methods: Computed tomography imaging was used to assess hepatic fat content in 80 men and women with type 2 diabetes. Inclusion criteria included a confirmed diagnosis of type 2 diabetes (≥1 year of duration), without history of hepatic disease or daily consumption of alcohol drink. The ratio of liver to spleen attenuat...

ea0020p131 | Thyroid | ECE2009

Regression of pulmonary arterial hypertension after treatment of hyperthyroidism

Quidute Ana Rosa , Paiva Joyce , Fernandes Virginia , Ponte Clarisse , Magalhaes Rejane , Montenegro Renan , Farias Ana Gardenia , Sobrinho Carlos Roberto Rodrigues , Junior Renan Montenegro

Several pathological processes contribute to the development and progression of pulmonary arterial hypertension (PAH), which is a disorder with high morbidity and mortality rates. However, although cardiac manifestations are common in hyperthyroidism (HT), they have been seldom described in association with HT. Thus, the objective of this study was to evaluate echocardiographic parameters in patients with Graves Disease (GD) during uncontrolled hyperthyroidism and after its re...

ea0049ep883 | Growth hormone IGF axis - basic | ECE2017

A surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH)

Farhat Khalil , Bodart Gwennaelle , Renard Chantal , Desmet Christophe , Moutschen Michel , Baron Frederic , Beguin Yves , Salvatori Roberto , Matens Henri , Geenen Vincent

In the framework of close interactions between the immune and neuroendocrine systems, Growth Hormone (GH) has been proposed to exert significant effects on the immune system, but there is not yet a consensus about GH immunomodulatory properties. These studies investigated the immune and anti-infectious response of dwarf Ghrh−/− mice presenting a severe deficiency of the GHRH/GH/IGF-1 axis. In basal conditions, thymic parameters and T-cell respon...

ea0020p505 | Obesity and Metabolism | ECE2009

Anthropometric parameters and non alcoholic hepatic steatosis in type 2 diabetes

Hachmi Leila Ben Salem , Bouzid Chiraz , Farhat Leila Ben , Dorai Azza , Waghlani Ridha , Hendaoui Lotfi , Slama Claude Ben

Aim: The aim of the study was to assess the association between anthropometric parameters and non alcoholic hepatic steatosis in type 2 diabetes.Methods: Computed tomography imaging was used to assess hepatic fat content in 80 men and women with type 2 diabetes. Inclusion criteria included a confirmed diagnosis of type 2 diabetes (≥1 year of duration), without history of hepatic disease or daily consumption of alcohol drink. Clinical and biochemica...

ea0090ep274 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

New onset diabetes and COVID-19 and: what type?

Asma Gorchene , Ach Taieb , Sahli Jihene , Asma Ben Abdelkarim , Ben Hadj Slama Nassim , Elfekih Hamza , Saad Ghada , Chaieb Molka Chadli , El Euch Koussay

Introduction: During the COVID-19 pandemic, an increase of new-onset diabetes has been reported in various diabetes centers with many studies speculating an auto-immune-triggering mechanism while other studies hypothesizing an increase of type 2 diabetes (T2D).Aim: The aim of this study is to compare the type of new-onset diabetes presenting with a diabetic ketoacidosis and its prevalence in the pre-pandemic vs pandemic COVID-19.Me...

ea0081ep1129 | Thyroid | ECE2022

Management of refractory Graves’ disease

Abir Meherzi , Sghaier Habiba Ben , Bellakhdhar Mouna , Malika El Omri , Houas Jihene , Wassim Kermani , Mohamed Abdelkefi

The goal of this paper is to analyze the factors that cause people to flee medical treatment and to put forth management guidelines. Materials and methodes: This is a retrospective analysis of 27 instances with Graves’ disease that were resistive to medical treatment after escaping from well-conducted medical treatment in the ENT and cervico-facial surgery departments at Farhat Hached Sousse Hospital over a six-year period [2015-2021]. Results: All of the patients were pu...

ea0081ep1218 | Late Breaking | ECE2022

Oncocytic carcinoma of the thyroid: Therapeutic and diagnostic challenge

Abir Meherzi , Njima Marwa Ben , Jemli Safa , Sghaier Habiba Ben , Bellakhdher Mouna , Houass Jihene , Wassim Kermani , Mohamed Abdelkefi

Background: To study the diagnostic difficulties, the clinical characteristics, as well as the therapeutic modalities of this entity.Material and method: Report a case of oncocytic carcinoma of the thyroid of aggressive evolution collected in the ENT department and CCF Farhat Hached in Sousse. Result: This is a 54-year-old patient, with no notable history, who was operated on in 2012 for a large goiter evolving for 3 years previous...