Endocrine Abstracts

Inconsistences in hirsutism evaluation using The Modified Ferriman-Gallwey scale (mFG) between different evaluators and need for hirsutism diagnostics standardization has been reported in numerous publications.The aim of the study was to determine the differences in the evaluation of female hirsutism between researchers.Results: The study included healthy 20–34 year old (mean age 25.2 years, 95% CI 23.8–26.5) women with r...

In euthyroid women normal pregnancy is associated with a rise in free thyroxine and fall in TSH levels attributable to high levels of hCG in the first trimester. In hypothyroid women free thyroxine tends to fall and TSH rises if the dose of thyroxine is not raised, due to further pregnancy - associated changes including a rapid rise in thyroxine-binding globulin and increased renal clearance and placental metabolism of thyroid hormone. Fetal thyroid development occurs by 12 we...

Case report: Hirsutism although common in acromegaly (24%) is not considered as the prevalent symptom of the disease. Here we describe a seventy-one year old woman with a 2-year history of hyperandronism and subtle acromegalic features (macroglossia, sleep apnea). Clinical examination showed hirsutism (Ferrimann-Gallwey score 20/34), acanthosis nigricans and mild clitoridomegaly. Blood examination revealed elevated IGF-1: 502 ng/ml (69–200 ng/ml) and standard oral glucose...

Introduction: Prolactinoma account for 40% of all pituitary tumors. It is the most common cause of hyperprolactinemia. Infertility, galactorrhea and hirsutism are the significant symptoms. Polycystic ovary syndrome affects the 5–10% of the women in reproductive age. The most common symptoms are irregular menses, hirsutism and infertility. However, prolactinoma and PCOS association is rare. A case of PCOS and prolactinoma is reported.Case: A 21-year-...

Hyperandrogenism in adolescent girls is medical and social problem, including hirsutism, seborrhea, severe acne, alopecia and hyperclitoridism.Purpose: To study the frequency and clinical peculiarities of the hyperandrogenism (HA) in adolescent girls.Patients and methods: The study included 2369 girls (aged 11–19 years). Patients were subjected to the clinical examination, ultrasound examination. Index of hyperandrogenism (HAI...

Aim: To determine whether metformin has beneficial effects on hirsutism in patientswithout diabetes mellitus.Methods: This was a randomised placebo controlled double blind parallel study of six months Metformin (1500milligrams per day)/placebo. The primary outcomes were change in hair growth rate on hirsutography and by Ferriman-Galwey score. Secondary endpoints were changes in biochemical parameters related to androgens and ins...

Introduction: 21-hydroxylase deficiency represents 95% of congenital adrenal hyperplasia. The non-classical form manifests in women mainly by hirsutism, menstrual disorders, or infertility. We present three patients’ cases.Observations: Patient N.C., 17 years old, who presented with hirsutism beginning at the age of 8 years and progressively worsening after puberty. The patient had her menarche at the age of 9 years, with short and irregular menses....

Introduction: We aimed to investigate serum galanin-like peptide levels and its’correlation with hormonal and metabolic parameters in patients with polycystic ovary syndrome (PCOS)Material and Methods: The study included 48 women (age range, 18-44 years) with a diagnosis of PCOS and control group that included 40 healthy females (age range, 18-46 years). Body mass index (BMI), waist circumference, Ferriman-Gallwey score, was evaluated and plasma glu...

Aim: The aim of this study was to evaluate hormonal disturbances and adipokines levels in girls with oligomenorrhea.Materials and methods: The study comprised a group of 46 girls, aged 16–18 years, who were diagnosed with oligomenorrhea, and a control group with 37 healthy girls, aged 16–18 years, with no diagnosed menstrual disorders. In the first stage of the study, all girls had their medical history assessed. Subsequently, anthropometric me...

The androgen receptor (AR) polymorphism is determined by a variable number of CAG triplets in exon 1 of the AR gene, located on the X chromosome. CAG polymorphism could modulate different hyper- or hypoandrogenic conditions, but its influence on the polycystic ovarian syndrome (PCOS) in different ethnic populations is controversial. Therefore, we investigated the influence of the AR polymorphism on the hormonal factors and clinical signs in 52 women with PCOS and in 41 non-hir...