Searchable abstracts of presentations at key conferences in endocrinology

ea0011p234 | Cytokines and growth factors | ECE2006

Possible predictive value of IGF-II mRNA expression in breast cancer (BC)

Giani CG , Giustarini EG , Fierabracci PF , Campani DC , Lippman MEL

Insuline like growth factor II (IGF II) is an important regulator of neoplastic growth and it is stromal in origin. Estrogen and Progesterone receptor (ER, PR) are considered a good prognostic predictors in BC. The aim of the study was to evaluate the impact of IGF II mRNA expression in the clinical outcome in breast malignancy. The study group included 75 women (mean age ±S.D.=53.3±15.6 yr) submitted to radical mastectomy for ductal infiltrating breas...

ea0011p485 | Endocrine tumours and neoplasia | ECE2006

Thyroid autoimmunity disorders and breast cancer (BC): absence of morphological autoimmune changes in breast malignant tissue

Giustarini EG , Pinchera AP , Fierabracci PF , Campani DC , Giani CG

Thyroid autoimmunity and BC are strongly related, but the cause of this association is unknown. In BC an increase of lymphoid cell infiltrates may be detected very early during tumor development. BC cells share some antigenic properties similar to those detected in thyroid tissue, as NIS and peroxidase activity and it is possible that in patients with BC and thyroid autoimmunity, should be present serum immunoglobulins reacting with these specific antigenes.<p class="abste...

ea0014p399 | (1) | ECE2007

Prevalence of primary hyperparatiroidism in treated and untreated breast cancer

Giani Claudio , Fiore Emilio , Giustarini Elisa , Muller Ilaria , Vignali Edda , Fierabracci Paola , Pinchera Aldo

Hypercalcemia is a frequent metabolic disorder in metastatic breast cancer (BC). Aim of this study was to evaluate the incidence of hypercalcemia due to PHPT in BC patients. The study group included 271 consecutive BC, mean age±S.D. 57.7±11.96 yrs. 100/271(36.9%) evaluated at different times after mastectomy (A) and 171(63.1%) before surgery (B), with no distant metastases. Age matched control group included 108 healthy women (Co) and 70 women with thy...

ea0011p235 | Cytokines and growth factors | ECE2006

IGF II protein expression in breast cancer. Relationship with the most important predictive parameters in breast malignancy

Giustarini EG , Pinchera AP , Campani DC , Fierabracci PF , Cullen KC , Giani CG

Recent in situ hybridization data showed high content of IGF-II mRNA in the stroma of breast cancer. The aim of this study was to examine the expression of IGF-II protein and its relationship with several prognostic parameters in 75 ductal infiltrating carcinoma (DIC) of the breast.The tissue sections were evaluated for IGF II protein, proliferating activity, ER, PR, p53, P21 oncogene expression using immunohistochemical procedures. The amoumt of ...

ea0011p343 | Diabetes, metabolism and cardiovascular | ECE2006

Obesity and expression of serotonin transporter (SERT) in human platelets

Marsili A , Santini F , Pelosini C , Betti L , Fabbrini L , Galli G , Ricco I , Baroni S , Italiani P , Fierabracci P , Giannaccini G , Pinchera A

Serotonergic transmission is involved in eating behaviour and body weight control. Comparison of SERT properties in blood platelets and serotonergic synaptosomes suggests that the human platelet can serve as an appropriate model for the transport, metabolism and release of serotonin by serotonergic neurons.Aim of this study was to evaluate SERT expression in platelets obtained from overweight or obese subjects (OB) as compared with normal weight healthy volunteers (C), and to ...

ea0011p371 | Diabetes, metabolism and cardiovascular | ECE2006

Clinical, functional and polysomnographics parameters in severely obese patients

Giannetti M , Santini F , Di Giorgio M , Scartabelli G , Fierabracci P , Marsili A , Valeriano R , Ricco I , Galli G , Pucci A , Carpenè N , Vitti P , Palla A , Pinchera A

Obesity is a major cause of chronic hypoventilation and/or obstructive sleep apnea syndrome (OSAS). Aim of this study was to evaluate the prevalence of pulmonary dysfunction and the relationship between OSAS and several clinical, functional and polysomnographics parameters in severely obese patients. 101 subjects (68 females and 33 males) aged 49.2±13.2 years (mean±S.D.), with BMI 46.8±6.5 Kg/m2 were enrolled. Sleep quality and daytime ...

ea0011p381 | Diabetes, metabolism and cardiovascular | ECE2006

Effects of bariatric surgery on preclinical myocardial alterations in severe obesity and the related role of insulin resistance

Pucci A , Santini F , Di Bello V , Marsili A , Fierabracci P , Di Cori A , Palagi C , Delle Donne MG , Giannetti M , Anselmino M , Vitti P , Balbarini A , Pinchera A

Obesity is a well established risk factor for congestive heart failure. The existence of an ‘obese cardiomyopathy’ has been hypothesized, as the complex combination of the effects of both hemodynamic and metabolic alterations. Aim of this study was to analyze the effect of bariatric surgery on the early myocardial alterations detected in a group of severe obese patients by high frame rate integrated backscatter (IBS). Twenty severely obese patients (5 males, 15 femal...