Endocrine Abstracts

Abstract for Society for Endocrinology Conference 2003Category: Clinical case report (Young Endocrinologist)AbstractTitle: A CASE OF HYPERTHYROIDISM PRESENTING AS HAEMATOLOGICAL MALIGNANCYAuthors: K.M. Evans, D.E. Flanagan; Dept. of Endocrinology and Diabetes, Derriford Hospital, Plymouth, PL6 8DHA 30 yr old man was referred to the Haematology department with axil...

In recent years there has been significant progress in defining the genetic aetiology of neonatal diabetes with disease-causing variants identified in over 30 genes. These genes are all recognised as having a critical role in the development, function, or destruction of the pancreatic beta-cell. Targeted next generation sequencing allows for the rapid, simultaneous screening of all 30 known neonatal diabetes genes. This analysis provides an accurate genetic diagnosis for over ...

Introduction: Adrenocortical carcinoma is a rare malignancy with an incidence of 1–2 per milion population. We present our experience of three patients with adrenal incidentalomas which were subsequently confirmed to be metastatic adrenocortical carcinoma.Discussion: Our first case presented at 56 years of age with abdominal pain in the background of recent type 2 diabetes and history of alcohol related pancreatitis. CT sh...

Introduction: Adrenocortical carcinoma is a rare malignancy with an incidence of 1–2 per milion population. We present our experience of three patients with adrenal incidentalomas which were subsequently confirmed to be metastatic adrenocortical carcinoma.Discussion: Our first case presented at 56 years of age with abdominal pain in the background of recent type 2 diabetes and history of alcohol related pancreatitis. CT sh...

The adrenal glands are common metastatic sites of lung and other cancers. Secondary adrenal hemorrhage due to these metastases is extremely rare and to our knowledge, only 3 cases have been described in literature. We present a patient who developed hypoadrenalism due to bilateral adrenal hemorrhage secondary to adrenal metastases from lung carcinoma. A 66 year old man with a 3 year history of non-small cell lung cancer previously treated with neo-adjuvant chemo-radiotherapy p...

Objective: We reviewed the depth and length of hypoglycaemia in a cohort of patients undergoing Insulin Tolerance Tests (ITTs). We evaluated the safety of the test, its reproducibility and explored factors that might predict the optimal dose of insulin.Methodology: ITTs were performed at a teaching hospital in the south of England between 2005 and 2010.Result: The major indication for ITT was non-functioning pituitary macro adenoma...

We describe seven patients with pituitary apoplexy diagnosed between July 2009 and Oct 2010.Presentation and Management: Five patients presented with sudden onset headache, nausea and vomiting. One developed headache while on carbegoline and other presented with fluctuating level of consciousness.All but two patients were inpatients at the hospital when diagnosed and all had MRI scan of pituitary to confirm the diagnosis and any ma...

Introduction: High testosterone level lowers the seizure threshold in patients previously well controlled on medication.Clinical scenario: A 59-year-old male, with a history of complex partial seizure, having 12 years of seizure free period on phenytoin and lamotrigine, presented with short history of vomiting, positional headache, and visual impairment. A diagnosis of pitutary macro adenoma was made following a MRI scan of his head. He underwent a trans...

A 40-year-old woman was admitted for investigation of severe fatigue, abdominal pain, anorexia and myalgia over the preceding year. Past medical history included vitiligo, coeliac disease and depression. Initial investigations revealed hyperkalaemia, normocytic anaemia and hypercalcaemia with an inappropriately normal parathyroid hormone level. Low TSH with normal free T4 and T3 (0.02 milliunits per litre, 17.1 picomoles per litre and 6.3 picomoles per litre respectively) were...

Fasting hypoglycaemia may occasionally be caused by non islet cell tumours (NICTH). Mostly they are large retroperitoneal, intra-abdominal or intrathoracic tumours that are slow growing though malignant. We report a case of recurrent hypoglycaemia associated with metastatic ovarian carcinoma.About 66-year-old lady was admitted with increasing abdominal distension and shortness of breath over 6 weeks duration. There was no significant past medical history...