Endocrine Abstracts

Introduction: Mild hyperkalemia is a common side-effect of mineralocorticoid receptor antagonists (MRA), which can be precipitated by minimizing dietary salt intake. Restoration of salt intake can overcome diminished kaliuresis and restore potassium levels. Aim of this study was the evaluation of the effect of adequate salt consumption on plasma potassium levels in relation to the mean, maximum and minimum blood pressure (BP) in MRA-treated sodium-depleted hyperkalemic patient...

Introduction: Our goal was to monitor and control the blood glucose levels in inefficiently controlled insulin-treated patients with diabetes mellitus (DM). The target was to achieve an early detection of DM deregulation, to maintain accepted HbA1c levels through active intervention and to minimize the outpatient department visits.Description of methods/design: Twenty-six insulin-treated type 1 and 2 DM patients were enrolled (mean age 61.42±14.5 ye...

Objective: The Fas/Fas ligand (FasL) apoptotic pathway is activated in patients with autoimmune thyroid disease (AITD). It is believed that Fas and FasL expression in intrathyroidal T lymphocytes and thyrocytes is regulated in a manner resulting in thyroid cell apoptosis in Hashimoto’s thyroiditis (HT) or lymphocyte apoptosis in Graves’ disease (GD). The hypothesis that Fas and FasL may be differentially expressed on peripheral lymphocytes in patients with HT and GD ...

Introduction-objective: Fas-mediated thyroid cell apoptosis is differentially regulated in autoimmune thyroid disease (AITD) being up-regulated in Hashimoto’s thyroiditis (HT) and down-regulated in Graves’ disease (GD). The soluble form of Fas (sFas), lacking the transmembrane domain due to alternative splicing may inhibit apoptosis by binding to Fas ligand. In this preliminary study we examined whether sFas is also differentially expressed in patients with AITD....

Background: Existing interventional trials show high dietary protein intake can reduce glycaemia in type 2 diabetic (T2DM) individuals. At present, there is limited data on this relationship in a young, healthy population at risk of T2DM. This study investigates the association of animal and plant-based dietary protein intake on fasting blood glucose (FBG) and 2-hour oral glucose tolerance test (OGTT) concentrations in a young South-Asian population at high-risk of type 2 diab...

Aim: Primary goal was to determine whether the improvement of HbA1c, observed in inefficiently insulin-treated diabetes mellitus (DM) patients on a telemonitoring system, had a lasting effect following its discontinuation.Methods: Forty-seven DM patients (mean age 56.15±15.86 years, mean BMI 29.44±6.69 kg/m2, mean HbA1c 9.9±2.62%) and 25 insulin-treated matched controls (mean age 56.16±20.11 years, mean BMI 27.6±5.18 k...

Introduction: Adrenal incidentalomas (AI) with or without concomitant autonomous cortisol secretion can be associated with several metabolic alterations that may lead to increased cardiovascular risk. However, data regarding insulin resistance (IR) during long term follow-up of AI are scarce. The aim was to prospectively investigate the presence and evolution of IR in patients with AI between 2003 and 2014.Methods: Seventy three patients with AI for at l...

Introduction: Ultrasound-guided fine needle aspiration biopsy (US-FNAB) enables selective sampling of thyroid follicular cells while minimizing potential complications. Inadequate specimen sampling can lead to FNAB repeat. Our aim was to evaluate the morphological and cytological characteristics of thyroid nodules with US and rapid on-site evaluation of adequacy (ROSE).Methods: Two independent endocrinologists evaluated nodule characteristics of 171 US-F...

Introduction: Patients with adrenal adenomas appear to exhibit an appreciable prevalence of autonomous aldosterone secretion (AAS). Our aim was to evaluate the anti-hypertensive effect of targeted therapy with mineralocorticoid receptor (MR) antagonists in AAS patients.Patients and methods: We studied 60 hypertensive patients, 21 males and 39 females, harboring an adrenal adenoma with AAS. All patients were receiving combination of anti-hypertensive trea...

Introduction: The prevalence of autonomous aldosterone secretion (AAS) in hypertensive subjects varies due to the use of various suppression tests and cut-off values. Our aim was to evaluate the prevalence of AAS in hypertensive subjects and test the anti-hypertensive effect of targeted treatment of the renin angiotensin II aldosterone system (RAAS) in AAS subjects.Description of methods/design: We investigated 336 hypertensive subjects with and without ...