Endocrine Abstracts

Objective: Benzodiazepines are among the most commonly used symptomatic treatment of insomnia and anxiety. Human and animal studies suggest that benzodiazepines suppress the hypothalamo-pituitary adrenal (HPA) axis. We report on a rare case of isolated ACTH deficiency due to long-term treatment with flunitrazepam.Case report: A 66-year-old man presented to our outpatient department with persistent feelings of physical exhaustion, low vitality, reduced da...