Searchable abstracts of presentations at key conferences in endocrinology

ea0016p661 | Signal transduction | ECE2008

NOD proteins expression and function in the pituitary folliculostellate cells

Correa-de-Santana Eliane , Frohlich Bianca , Theodoropoulou Marily , Paez-Pereda Marcelo , Onofri Chiara , Labeur Martha , Renner Ulrich , Karl Stalla Gunter

Folliculostellate (FS) cells were found to regulate hormonal secretion in pituitary endocrine cells. This cell type share properties with components of the innate immune response such as dendritic cells and macrophages, and it is suggested that they are able to initiate immune responses and act as part of an immunoendocrine regulation system. Members of toll-like receptor (TLR) family recognize bacterial cell wall components and initiate an immune response. Recently, we detect...

ea0011p472 | Endocrine tumours and neoplasia | ECE2006

Stimulated and spontaneous growth hormone release in irradiated acromegalic patients

van der Klaauw AA , Pereira AM , van Thiel SW , Smit JWA , Corssmit EPM , Biermasz NR , Frohlich M , Iranmanesh A , Veldhuis JD , Roelfsema F , Romijn JA

Growth hormone deficiency frequently occurs as consequence of radiation therapy in pituitary disorders. However, it not known whether radiation therapy in acromegaly results in comparable diminution of GH secretion. We therefore hypothesized that stimulated and spontaneous GH release is ultimately indistinguishable in irradiated acromegalic patients and irradiated patients with other pituitary disorders. For this study 10 acromegalic patients and 10 patients with other pituita...