Endocrine Abstracts

For decades, measurements of the circulating concentrations of GH and IGF1 have constituted a mainstay in the diagnosis and clinical management of GH disorders. However, it is also well-known that considerable discrepancies exist between different assays, resulting in highly assay dependent results. Therefore, in 2009 an International Expert Committee was established with the aim to produce an international consensus statement on the standardization and evaluation of GH and IG...

Introduction: The GH/insulin-like growth factor 1 (IGF1) system may modulate the pituitary-gonadal axis in males. Direct pituitary and/or testicular effects might be involved, as well as indirect effects on sex hormone binding globulin (SHBG) and aromatase activity.Methods/design: Nine healthy male volunteers (mean age 37, range 29–49 years) were treated in random order with increasing doses of GH for three weeks (1st week 0.01, 2nd week 0.02, 3rd 0...

Introduction: Observations in patients with GH disturbances and in normal populations have suggested that GH/IGF1 activity could have anti-inflammatory effects. On the other hand, in vitro studies have shown that IGF1 may stimulate the immune system.Methods/design: The study population consisted of 12 healthy volunteers (mean age 36, range 27–49 years) treated with GH for 3 weeks (1st week 0.01 mg/day, 2nd 0.02 mg/day, 3rd 0.03 mg/day) and su...

ObjectiveIt has been suggested that ghrelin may play a role in regulating the growth hormone (GH) response to exercise. This study was designed to determine whether very intense exercise alters circulating ghrelin concentrations. Design: Following Local Ethics Committee approval, 7 male volunteers were familiarised before completing two trials in a random order. In one trial participants performed a single 30-s sprint on a cycle ergometer, in the ...

Introduction: Type 1 diabetes (T1D) is characterized by primary insulin insufficiency and secondary disruption of GH–IGF–IGFBP axis. S.c. insulin therapy is necessary to normalize this axis. This study aimed to investigate whether the distinct insulin profiles obtained with insulin aspart and human insulin preparations, respectively, affect IGF1 concentration and bioactivity and IGFBP levels differently.Methods: In a randomized, four-period cro...

Background: Visceral adipose tissue (VAT) is less insulin sensitive and more harmful than subcutaneous adipose tissue (SAT). In adipocytes, IGF1 receptor signaling has been linked to insulin resistance, but it is unknown whether VAT and SAT also differ in production of IGFs. Therefore, we compared IGFs, IGFBP-4 and PAPP-A production in cultured fragments of VAT and SAT from obese subjects.Methods: VAT and SAT was collected perioperatively during elective...

Objectives: Insulin interacts with the GH – insulin-like growth factor (IGF) system by a reciprocal regulation of IGF-binding proteins (IGFBPs) and GH, which in turn interact to regulate insulin sensitivity (IS). We previously showed that IGFBP-2 is involved in the insulin-induced reduction in IGF1 bioactivity. We here address the modulation of IGF1 bioactivity during acute lipid-induced insulin resistance.Methods: 18 healthy men (30.8±2.6 year...

Aims: To compare the pharmacokinetic and pharmacodynamic profiles of insulin aspart, biphasic insulin aspart 70 (BIAsp70), biphasic insulin aspart 50 (BIAsp50) and soluble human insulin under experimental conditions.Methods: In this randomised, four-period crossover study, 19 type 1 diabetic patients received subcutaneous injections of identical doses (0.2 U/kg) of either insulin aspart, BIAsp70, or BIAsp50 immediately before a standardized meal, or huma...

Introduction: α-Defensins are recently described peptides, which are part of the innate immune system. Increased circulating levels are observed in conditions associated with chronic low grade inflammation, such as ischemic heart disease and in diabetes mellitus (DM). Recently we reported adverse prognostic implications of high α-defensins in patients with type 1 DM. However, it is not clear whether this finding may be generalized to include other groups such as pati...

Context and objective: During fasting growth hormone (GH) promotes lipolysis, attenuates glucose oxidation and preserves protein. Previous studies have primarily been conducted in GH deficient patients or during somatostatin-suppression of GH secretion. We aimed to study the impact of the fasting associated increase in GH without concomitant changes in other hormones, by the means of GH receptor (GHR) blockade.Design: Ten healthy young men participated i...