Searchable abstracts of presentations at key conferences in endocrinology

ea0049s9.2 | Novel type 2 diabetes treatment: Beyond glycaemic control | ECE2017

Clinical studies on GLP1 - cardiovascular outcomes

Gallwitz Baptist

The incretin hormone Glucagon-like peptide-1 (GLP-1) has various non-glycaemic properties. Among those, cardiovascular effects have been described in animal studies and in clinical studies in patients with type 2 diabetes that have been treated with GLP-1 receptor agonists (GLP-1RA). In animal studies, GLP-1 and GLP-1RA have lead to a decrease in ischaemic areas in artificial myocardial infarct models. Additionally, in some clinical studies, an improvement in left ventricular ...

ea0020d1.3 | What to do next when Metformin does not work in Type 2 Diabetes? | ECE2009

What to do next when metformin does not work in diabetes Type 2? add incretin

Gallwitz Baptist

Near-normoglycaemia shold be reached as safely as possible. It should be considered, that at lower HbA1c concentrations, the proportional contribution of postprandial glucose to HbA1c is greater than at higher HbA1c values.Sulfonylureas, glinides and insulin are associated with an increased risk for hypoglycaemia and weight gain. Therefore, these agents should not be considered in first line for the combination therapy in overweight patients with Type 2 ...

ea0016p21 | Adrenal | ECE2008

11β-hydroxysteroid dehydrogenase 2 activity is elevated in extreme obese subjects and negatively associated with insulin sensitivity

Mussig Karsten , Remer Thomas , Haupt Axel , Gallwitz Baptist , Fritsche Andreas , Haring Hans-Ulrich , Maser-Gluth Christiane

Objectives: Alterations in glucocorticoid (GC) metabolism may contribute to the development of obesity and insulin resistance. We aimed to study the role of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in human adiposity, paying special attention to the association between altered GC metabolism and insulin sensitivity.Design: In 24-h urine samples of 72 extremely obese (mean BMI 45.5±1.1 kg/m2), but otherwise healthy patie...

ea0016p727 | Thyroid | ECE2008

Hashimoto’s thyreoiditis is associated with an increased occurrence of deficits in attention testing compared to patients with other thyroid illnesses

Mussig Karsten , Leyhe Thomas , Weinert Claudia , Saur Ralf , Klingberg Stefan , Gallwitz Baptist

Objectives: Experimental and clinical data point to an involvement of the central nervous system in Hashimoto’s thyroiditis (HT) independent of thyroid dysfunction. The neuropsychological function of patients with HT has not been systematically evaluated yet.Design: In the present prospective study, neuropsychological testing was performed in 26 euthyroid patients with HT compared to 25 euthyroid patients with hormonal treatment for goitre or after ...

ea0011p52 | Clinical case reports | ECE2006

Infertility and bilateral testicular masses due to 21-hydroxylase deficiency

Müssig K , Kaltenbach S , Maser-Gluth C , Hartmann MF , Wudy SA , Horger M , Gallwitz B , Raue F , Häring H-U , Schulze E

Objective: Congenital adrenal hyperplasia results from 21-hydroxylase deficiency in more than ninety percent of cases. The classical form of 21-hydroxylase deficiency presents in the neonatal period with virilization or adrenal insufficiency, with or without concurrent salt wasting. We report on a rare case of classic 21-hydroxylase deficiency diagnosed in late adulthood.Case report: A 39-year-old male patient presented for workup of infertility. Urologi...

ea0088023 | Abstracts | BES2022

Is this just vitiligo? Nelson is hiding

Vis M De , S Deweer , B Velkeniers

Introduction: Autoimmune disease is a rare event occurring after remission of Cushing’s syndrome. We report on the appearance of new onset vitiligo in a patient treated for Cushing disease due to a an invasive pituitary adenoma, after bilateral adrenalectomy.Case report: A 64-year-old man presented to our endocrinology clinic with progressive lumbar pain that had developed two months earlier. He had undergone bilateral adrenalectomy for Cushing&#146...