Endocrine Abstracts

Introduction: TSH suppression therapy by thyroid hormones (TST) in patients with differentiated thyroid cancer (DTC) could be associated with adverse effects on bone metabolism in post-menopausal women. Recent recommendations suggest therefore to minimize time passed under TSH suppression therapy. However data in literature are controversial and few shows results on microarchitecture. This study evaluated bone microarchitecture using High-resolution peripheral quantitative com...

Background: Restrictive anorexia nervosa (AN) presents an adaptive appetite regulating profile including mainly high levels of ghrelin. Because this adaptive mechanism is not effective on food intake, other appetite regulating peptides need to be explored. 26RFa is a hypothalamic neuropeptide that stimulates appetite, gonadotropin release and bone metabolism. The aim of the current study was to evaluate circadian levels of 26RFa in AN patients compared with healthy subjects, o...

Introduction: Opioid system activity was found disturbed in several reward circuit areas in restrictive anorexia nervosa (AN) patients but also surprisingly at the pituitary level. However, the potential role of this specific abnormality of pituitary in AN physiopathology remains unclear or unknown.Objectives: The first aim was to find the exact pituitary location (posterior and/or anterior) of this disturbed opioid activity and then to study the link be...

Introduction: Constitutional thinness (CT) is an underweight state characterized by normal menstruations and no change in feeding behaviour. Thinness is the only resemblance between Anorexia Nervosa (AN) and CT. Removal of amenorrhea in the new DSM 5 definition of AN might lead to misdiagnosis between these two populations. The objective of this study was to compare CT, AN and Control subjects in terms of biological, anthropometric, and psychological markers in order to better...

Thyroid dysplasia (ectopy, hypoplasia or aplasia) is a common cause of congenital hypothyroidism. Lingual thyroid is a rare embryological aberration caused by failure of migration of the thyroid gland to its normal position in the neck.This retrospective study involved 30 patients with lingual thyroid diagnosed in our Department between 1970–2005. The diagnosis was based on physical examination, evaluation of the mental development (IQ) and following tests:TSH, fT4, ultra...

Energy balance is controlled by the arcuate nucleus through integration of peripheral hormonal signals such as leptin, ghrelin, peptide YY (PYY) and glucagon like peptide 1 (GLP-1). The commonest reason for young women in the developed world to be underweight is restrictive anorexia nervosa (AN). Constitutionally thinness (CT) has been described in young women who satisfies the WHO definition for moderate to severe underweight (BMI 13–16.9 kg/m2). CT women have...

Introduction: Pulsatile GnRH therapy is currently used to restore LH pulse and induce physiological ovulation, with effectiveness demonstrated in all types of hypothalamic amenorrhea (HA). Anorexia nervosa (AN) is characterized by self-starvation-induced undernutrition leading to functional hypothalamic amenorrhea (HA). Weight recovery does not always restore menses despite no apparent clinical and biological undernutrition residual signs. Only few specific studies on persiste...

Introduction: Constitutional thinness (CT) is a rare condition of natural low body weight, with normal menstruation, no fear of weight gain and no hormonal abnormalities except for an anorexigenic hormonal profile. CT can be considered as the opposite of obesity and its resistance to weight loss. Therefore, we hypothesised they would have a resistance to weight gain.Methods: 10 female Controls (BMI 18.5–25 kg/m2) and 10 CT women (BMI<...

The critical problem of thyroid nodules is to identify the malignant ones Fine needle aspiration biopsy (FNAB) plays a crucial role in this diagnosis and enables the number of surgical operations to be reduced. We have evaluated the performances of FNAB in comparison with the histological examination in 1971 consecutive patients who suffered both fine-needle puncture and surgery in a 5 years interval at a University Hospital. FNAB was malignant or suspicious in 8.4% patients, ...

Medullary thyroid carcinoma (MTC) is a rare tumoral entity related to parafollicular C cells of the thyroid gland, characterized by peculiar morphological, functional and evolutional features. The aim of this study was to characterize the cases of medullary carcinoma diagnosed in a university hospital in a 5 years interval (January 1999–December 2003) and to evaluate the diagnostic methods. In this time interval, from a total of 171 thyroid malignancy, 12 (7%) were medull...