Searchable abstracts of presentations at key conferences in endocrinology

ea0086cc2 | Featured Clinical Case Posters | SFEBES2022

Coexistence of cranial diabetes insipidous and heart failure with reduced ejection fraction: a case report presenting challenges and unique therapeutic opportunities

Efthymiadis Agathoklis , H P Gamble James , Pal Aparna

History: We present the case of a 47-year-old man with heart failure (HF) and cranial diabetes insipidus (CDI) secondary to Langerhans-cell-histiocytosis. In the context of worsening HF with increasing shortness of breath and fluid retention, careful desmopressin dose reduction provided adequate aquaresis to restore euvolemia, obviating the need for usual diuretic treatments.Investigations: Echocardiography and a cardiac MRI revealed a non-dilated but se...

ea0005s6 | Androgens and Prostate Cancer | BES2003

Androgen action in the prostate

White H , Gamble S , Odontiadis M , Bevan C

Prostate growth during development and at puberty is dependent on androgens. After puberty, growth ceases and the secretory function of the organ is maintained in the presence of high circulating testosterone levels. However, in cases of benign prostatic hyperplasia and prostate cancer, growth resumes inappropriately. Like normal prostate growth, tumour growth is initially androgen-dependent; hence, treatment involves removing circulating androgens by chemical castration and o...

ea0024oc1.1 | Oral Communications 1 | BSPED2010

Best Abstract Winner

Ng S M , Turner M A , Gamble C , Didi M , Newland P , Victor S , Manning D , Settle P , Gupta R , Abernethy L , Parkes L , Atkinson J , Weindling A M

Background: Low thyroid hormone concentrations in the first few weeks of life in preterm infants may be linked with poor neurodevelopment. We conducted a multi-centred randomised controlled trial of thyroxine (T4) supplementation in babies born under 28-weeksÂ’ gestation (TIPIT study). A post hoc subgroup analysis was undertaken to examine brain growth and development.Methods: Seventy-eight infants received T4 supplementation an...

ea0066oc2.1 | Oral Communications 2 | BSPED2019

National United Kingdom evidence- and consensus-based guidelines for the investigation, treatment and long-term follow-up of paediatric craniopharyngioma

Gan Hoong-Wei , Morillon Paul , Albanese Assunta , Aquilina Kristian , Barkas Konstantinos , Chandler Chris , Chang Yen-Ch'ng , Daousi Christina , Drimtzias Evangelos , Farndon Sarah , Jacques Tom , Korbonits Marta , Kuczynski Adam , Limond Jennifer , Robinson Louise , Simmons Ian , Thomas Nick , Thomas Sophie , Thorpe Nicola , Vargha-Khadem Faraneh , Warren Daniel , Zebian Bassel , Gamble Ashley , Wilne Sophie , Harrison Barney , Spoudeas Helen , Mallucci Conor

Aims: Although rare, craniopharyngiomas are the commonest suprasellar tumour in childhood. Despite high overall survival, children and young people <19 years with craniopharyngiomas are at risk of multiple relapses and long-term tumour- and treatment-related morbidity. We sought to provide, for the first time, a national standard for best practice based on currently available evidence for the assessment, treatment and follow-up of paediatric craniopharyngiomas under the au...

ea0028cmw2.2 | Controversies in aetiology and management of osteoporosis | SFEBES2012

Osteoporosis and metabolic bone disease in adolescence

Bishop Nick

The diagnosis of osteoporosis in the context of the growing skeleton requires both the presence of low bone mass for body size and a history of low trauma fractures. The presentation of osteoporosis may predate adolescence, or less commonly arise during that period. Primary osteoporosis is typically due to osteogenesis imperfecta or idiopathic juvenile osteoporosis. Secondary osteoporosis arises as a result of a variety of conditions, most of which fall under thematic headings...