Searchable abstracts of presentations at key conferences in endocrinology

ea0014p572 | (1) | ECE2007

Impairment of GH secretion by ghrelin stimulation test in primary hyperparathyroidism (PHP)

Cecconi Elisabetta , Giovannetti Clara , Manetti Luca , Raffaelli Valentina , Procopio Massimo , Ghigo Ezio , Gasperi Maurizio , Martino Enio

Pituitary GH secretion is regulated by the interplay of at least two hypothalamic hormones, GH-releasing hormone (GHRH) and somatostatin, through their interaction with specific cell surface receptors on the anterior pituitary somatotrophs. A third type of receptor, the growth hormone secretagogue receptor, called GHS receptor type 1a (GHSR1a), was identified in the pituitary and the hypothalamus. Ghrelin is an acylated peptide produced predominantly by stomach and a natural l...

ea0014p571 | (1) | ECE2007

Riluzole treatment does not affect growth hormone (GH) secretion in amyotrophic lateral sclerosis

Morselli Lisa Linda , Bongioanni Paolo , Genovesi Maura , Licitra Rosaria , Rossi Bruno , Murri Luigi , Gasperi Maurizio , Martino Enio

Amyotrophic lateral sclerosis (ALS), the most common motor neurone disorder in human adults, presents is characterized by selective and progressive degeneration of upper and lower motor neurones in central nervous system. GH secretion, evaluated by GHRH+arginine test, has been recently reported to be impaired in about 70% of untreated ALS patients. The currently available drug for ALS treatment is riluzole, a compound acting through inhibition of glutamate relase, post-synapti...

ea0011p23 | Bone | ECE2006

The reduction of bone mineral density in post-menopausal women with primary hyperparathyroidism is higher in the presence of concomitant GH hormone secretion impairment

Cecconi E , Genovesi M , Bogazzi F , Grasso L , Procopio M , Marcocci C , Pinchera A , Bartalena L , Martino E , Gasperi M

Primary hyperparathyroidism (PHP) and growth hormone deficiency (GHD) are both associated with alterations of bone metabolism.GH secretion is frequently impaired in PHP patients; thus GH/IGF-I system alterations could be involved in the pathogenesis of osteoporosis.In the present study 50 post-menopausal women with PHP were evaluated by GH response to GH-releasing hormone (GHRH)+arginine (ARG) test and femoral neck bone mineral den...

ea0011p593 | Neuroendocrinology and behaviour | ECE2006

Differentiation of TSH-oma from thyroid hormone resistance syndrome using thyroid color Doppler sonography

Cosci C , Sardella C , Manetti L , Gasperi M , Tomisti L , Gavioli S , Macchia E , Bogazzi F , Martino E

Thyroid hormone resistance (THR) and pituitary TSH-secreting adenomas (TSHoma) are both characterised by increased serum free thyroid hormone levels and normal TSH concentrations. Differentiation of the two syndromes is a clinical challenge, and relies on the suppression (TRH) or lack of suppression (TSHoma) of TSH-dependent parameters and on the presence of germinal mutations in the thyroid hormone receptor beta 1 gene in patients with THR. Thyroid blood flow, evaluated using...

ea0011p614 | Neuroendocrinology and behaviour | ECE2006

Pituitary function in patients with detectable serum pituitary autoantibodies

Morselli LL , Manetti L , Lupi I , Albertini S , Grasso L , Fessehatsion R , Genovesi M , Gasperi M , Martino E

Pituitary autoantibodies have been detected in patients with endocrine autoimmune diseases as well as in various pituitary diseases but their role in determining pituitary dysfunction is not clear. The aim of the present study was to evaluate anterior and posterior pituitary function in a group of patients with detectable pituitary autoantibodies.31 patients (29 women and 2 men) were enrolled in the study: 21 patients affected by Hashimoto’s thyroid...

ea0032p830 | Pituitary–Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Mutations of SOX2 gene: a novel heterozygous mutation and impact on congenital hypopituitarism

Auriemma Renata S , Macchiaroli Annamaria , Kelberman Daniel , Faienza Maria F , Corona Rosalia , Mariano Iolanda , Giangiobbe Sara , Galdiero Mariano , Pivonello Rosario , Colao Annamaria , Gasperi Maurizio

Introduction: Anophthalmia/microphthalmia is a rare developmental craniofacial defect often associated to congenital hypopituitarism with GH deficiency and hypogonadism. SOX2 gene plays a key role in embryonic development regulation and heterozygous mutations of this gene, reported only in 14 patients to date, have been associated to anophthalmia/microphthalmia and congenital hypopituitarism in uo to 10% of cases. Therefore, the study of the SOX2 gene can be clinically useful ...

ea0032p866 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effects of short (12 months) and long (60 months) term treatment with cabergoline on metabolic syndrome and visceral adiposity index in patients with hyperprolactinemia

Auriemma Renata S , Granieri Luciana , Perone Ylenia , Galdiero Mariano , Grasso Ludovica , Simeoli Chiara , Pivonello Claudia , Gasperi Maurizio , Giordano Carla , Colao Annamaria , Pivonello Rosario

Introduction: Hyperprolactinemia is reportedly associated with an impaired metabolic profile, particularly in patients with concomitant hypogonadism. The current study aimed at investigating the effects of short (12 months) and long (60 months) treatment with cabergoline (CAB) on metabolic complications, metabolic syndrome (MS) prevalence and visceral adiposity index (VAI) in hyperprolactinemic patients.Patients and methods: Seventy-one patients (51 F, 2...

ea0032p1129 | Thyroid cancer | ECE2013

Thyroid cancer frequency in acromegalic subjects

Chentli Farida , Meskine Djamila , Daffeur Katia , Azzoug Said , Fedala Nora Soumeya

Introduction: It is now well demonstrated that thyroid disorders are more frequent in acromegaly than in normal population. Our aim is to analyze thyroid cancer frequency in a cohort of Algerian subjects with acromegaly.Material and methods: It is a retro and prospective study where 77 hyper somatotropic subjects were enrolled (34F and 43M) mean age=39ans (12–58). Mean GH rate=59 ng/ml (7–597, n<5). All had clinical examination, ro...