Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep18 | Adrenal and Cardiovascular Endocrinology | ECE2020

Adrenal adenoma with hyperandrogenism and virilization in a postmenopausal women

Laura García María , Genovesi Elbio , Rella Noelia , Speroni Romina

Hyperandrogenism and virilization are infrecuent in postmenopausal women and may result from androgen-producing tumors. Androgen-secreting adrenal tumors are rare in clinical practice and often diagnosed as adrenocortical carcinoma, while benign androgen-secreting adrenal tumors are even more rare.Case presentation: A 63-year-old postmenopausal woman in follow-up for hypothyroidism reported hair loss, increased libido accompanied by deepening of the voic...

ea0022p5 | Adrenal | ECE2010

Evaluation of haemostatic and fibrinolytic markers in patients with Cushing's syndrome: a longitudinal study

Raffaelli Valentina , Manetti Luca , Ruocco Lucia , Giovannetti Clara , Genovesi Maura , Pellegrini Giovanni , Bogazzi Fausto , Martino Enio

Patients with active Cushing’s syndrome (CS) have an increased coagulability and thrombotic tendency. High glucocorticoids concentrations increase plasma clotting factors, especially von Willebrand factor (vWf) and reduced fibrinolytic capacity. Thromboemobolic complications, mainly in the postsurgical phase, have been reported.Aim of this longitudinal study was to evaluate haemostatic and fibrinolytic markers in patients with active Cushing’s ...

ea0022p564 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Use of cabergolin in Nelson's syndrome: preliminary results in four patients

Giovannetti Clara , Manetti Luca , Raffaelli Valentina , Cosottini Mirco , Genovesi Maura , Martino Enio

The Nelson’s syndrome (NS) is characterized by hyperpigmentation, sellar growing mass, and increased plasma ACTH concentrations The management of NS remains difficult: neurosurgery represent the first choice therapy. Many drugs have been used with variable results: cyproeptadine, GABA-agonists, somatostatin analogues, chemiotherapy, PPAR-γ-agonists, and dopamin-agonists.Aim of this study was to evaluate the efficacy of cabergoline administratio...

ea0011p585 | Neuroendocrinology and behaviour | ECE2006

GH secretion in amyotrophic lateral sclerosis

Morselli LL , Bongioanni P , Genovesi M , Licitra R , Rossi B , Martino E

Amyotrophic lateral sclerosis (ALS) is the most common motor neurone disorder in human adults. Scanty data on endocrine abnormalities have been reported. Aim of the present study was to investigate the GH-IGF-I axis in ALS patients.22 ALS patients (12 men and 10 women), aged 46–77 years, performed GHRH+arginine test: blood samples for GH were collected at baseline, 30 and 60 minutes; IGF-I was determined at baseline. The control group consisted of 2...

ea0014p571 | (1) | ECE2007

Riluzole treatment does not affect growth hormone (GH) secretion in amyotrophic lateral sclerosis

Morselli Lisa Linda , Bongioanni Paolo , Genovesi Maura , Licitra Rosaria , Rossi Bruno , Murri Luigi , Gasperi Maurizio , Martino Enio

Amyotrophic lateral sclerosis (ALS), the most common motor neurone disorder in human adults, presents is characterized by selective and progressive degeneration of upper and lower motor neurones in central nervous system. GH secretion, evaluated by GHRH+arginine test, has been recently reported to be impaired in about 70% of untreated ALS patients. The currently available drug for ALS treatment is riluzole, a compound acting through inhibition of glutamate relase, post-synapti...

ea0011p23 | Bone | ECE2006

The reduction of bone mineral density in post-menopausal women with primary hyperparathyroidism is higher in the presence of concomitant GH hormone secretion impairment

Cecconi E , Genovesi M , Bogazzi F , Grasso L , Procopio M , Marcocci C , Pinchera A , Bartalena L , Martino E , Gasperi M

Primary hyperparathyroidism (PHP) and growth hormone deficiency (GHD) are both associated with alterations of bone metabolism.GH secretion is frequently impaired in PHP patients; thus GH/IGF-I system alterations could be involved in the pathogenesis of osteoporosis.In the present study 50 post-menopausal women with PHP were evaluated by GH response to GH-releasing hormone (GHRH)+arginine (ARG) test and femoral neck bone mineral den...

ea0011p614 | Neuroendocrinology and behaviour | ECE2006

Pituitary function in patients with detectable serum pituitary autoantibodies

Morselli LL , Manetti L , Lupi I , Albertini S , Grasso L , Fessehatsion R , Genovesi M , Gasperi M , Martino E

Pituitary autoantibodies have been detected in patients with endocrine autoimmune diseases as well as in various pituitary diseases but their role in determining pituitary dysfunction is not clear. The aim of the present study was to evaluate anterior and posterior pituitary function in a group of patients with detectable pituitary autoantibodies.31 patients (29 women and 2 men) were enrolled in the study: 21 patients affected by Hashimoto’s thyroid...

ea0011p615 | Neuroendocrinology and behaviour | ECE2006

Prevalence of pituitary autoantibodies in thyroid disorders

Manetti L , Morselli LL , Lupi I , Albertini S , Grasso L , Genovesi M , Fessehatsion R , Mariotti S , Martino E

Organ-specific autoantibodies have been detected in patients with autoimmune diseases. The relationship between pituitary autoantibodies and lymphocitic hypophysitis has not yet been established and it is not clear if they are a specific serological marker of the disease.The aim of the present study was to evaluate the prevalence of pituitary autoantibodies in patients affected by autoimmune and nodular thyroid disorders.803 patien...

ea0073pep15.5 | Presented ePosters 15: Late Breaking | ECE2021

Pheochromocytoma secreting IL-6; an atypical presentation

Laura García María , Lisdero Ana Paula , González Pernas Mariana , Speroni Romina , Segarra Ana , Otero Jimena , Genovesi Elbio , Belli Susana , Giselle Mumbach Aizhar

Pheochromocytoma (PCC) is a rare tumor that arises from the adrenal medulla, usually presents with headache, sweating and palpitations due to excessive catecholamine release. However, PCC may secrete neuropeptides, hormones and cytokines, such as interleukin-6 (IL-6)) resulting in unusual clinical manifestations. A 48-year-old woman with a previous history of type 1 neurofibromatosis (NF1) and hypertension was referred to discarded PCC. Laboratory tests revealed leukocytosis a...