Endocrine Abstracts

Choriogonadotrophin-alpha (Cga) is one of the first molecular markers for the developing pituitary gland previously known as ‘alpha-subunit’, common to thyroid-stimulating hormone (TSH), luteinising hormone (LH) and follicle-stimulating hormone (FSH). Mice lacking Cga are hypogonadal and exhibit profound hypothyroidism and dwarfism. Light microscopy of Cga null mice has shown that pituitary thyrotrophs...

Choriogonadotrophin-alpha (Cga) is one of the first molecular markers for the developing pituitary gland previously known as ‘alpha-subunit’, common to thyroid-stimulating hormone (TSH), luteinising hormone (LH) and follicle-stimulating hormone (FSH). Mice lacking Cga are hypogonadal and exhibit profound hypothyroidism and dwarfism. Light microscopy of Cga null mice has shown that pituitary thyrotrophs...

We report a family with a novel heterozygous mutation of the menin gene. This gene encodes a tumor suppressor protein which is responsible for multiple endocrine neoplasia type 1. The index female patient presented with symptoms of mild gastric hyperacidity and recurrent kidney stones. Family history revealed, that the daughter, as well as two sisters of the index patient had operations for primary hyperparathyroidism (PHPT). Clinical studies in the index patient showed elevat...

Introduction: The autoimmune polyglandular syndrome is a complex, heterogeneous disease in which autoimmune diseases of endocrine and non-endocrine organs can occur. There are 4 subgroups: the early-onset APS I develops due to the mutation of the gene AIRE and characterized by the presence of Addison’s disease (AD), mucocutan candidiasis and hypoparathyroidism; the APS II is defined by the appearance of AD and autoimmune thyroid diseases (AITDs) and/or diabetes mellitus; ...

Introduction: Both cortisol and vasopressin are stress hormones. Earlier, our group demonstrated that serum concentrations of free cortisol at admissions to the Intensive Care Unit (ICU) were independent predictors of survival in critically ill patients. Other investigators have demonstrated that serum copeptin, a surrogate marker of vasopressin may also be a predictive factor in this patient population. The aim of our present study was to compare the prognostic roles of serum...

Introduction: The autoimmune polyglandular syndrome (APS) is a complex, heterogeneous condition in which autoimmune diseases (AIs) of endocrine and non-endocrine organs can occur. There are four subgroups. The majority of patients are categorized as having APS II or APS III. In APS II, patients have Addison’s disease (AD) and autoimmune thyroid diseases (AITDs) or type I. diabetes mellitus (T1DM), while in the APS III, AITDs are combined with other autoimmune illnesses ex...

Decreased bone mineral density (BMD) and disturbances in glucose metabolism are common complications of Cushing’s disease. Many recent studies have shown that hyperinsulinemia in type 2 diabetes mellitus (DM) may lead to higher BMD as compared to healthy individuals. The aim of the present study was to investigate the possible relationships between BMD, serum markers of bone metabolism and plasma cortisol concentrations. The second objective was to determine whether the p...

Many previous studies have shown decreased bone mineral density (BMD) in patients with endogenous hypercortisolism, although data on the severity of bone disease are contradictory. There are very sparse data about the correlations between plasma cortisol concentrations and BMD.The study included 188 patients with clinically inactive adrenal adenomas (IAA) and 30 patients with ACTH-independent Cushing’s syndrome (CS) due to adrenocortical adenomas. A...

Introduction: Significant hyponatremia may evolve in hypothyroidism, when however, elevated ADH levels have not been consistently demonstrated. On the other hand, it was shown that thyroid hormone substitution suppresses ADH, and its surrogate marker copeptin secretion. The aim of our present study was to investigate the possible humoral changes in a special model of resolution of short term severe hypothyroidism in differentiated thyroid cancer (DTC) patients.<p class="ab...

A 17-year-old boy was referred to our Department. In his medical history Crohn’s disease had been supposed because of abdominal pain and distention. He had previously undergone minor surgery as having large tongue with neuromas and hypertrophic gums. Due to his marfanoid appearance, arachnodactyly, massive eyebrows and lips together with his medical history, multiple endocrine neoplasia type 2B (MEN2B) was suspected, which is a very uncommon hereditary disease. It consist...