Endocrine Abstracts

Introduction: Childhood obesity continues to prove a major public health concern, with obesity and metabolic syndrome becoming increasingly prevalent in children and young people with type 1 diabetes mellitus (T1DM). Glucagon-like peptide 1 (GLP-1) therapy has shown promising results for weight loss in adults with type 2 diabetes mellitus (T2DM) and has recently been licensed for the treatment of adolescents living with obesity. Liraglutide has been shown to be beneficial in f...

Introduction: Non-alcoholic steatohepatitis (NASH) is part of the spectrum of non-alcoholic fatty liver disease (NAFLD). NASH commonly occurs in patients with type 2 DM and is less recognised in type 1 DM. The natural history of NASH in adult patients suggests potential development of progressive fibrosis and cirrhosis. However, secondary glycogenosis, commonly occurs in type 1 DM, is reversible when good glycaemic control is achieved, but may be misidentified as NASH b...

Introduction: Evidence is currently limited regarding the management of abnormal lipid profiles in children and young people (CYP) with Type 1 Diabetes Mellitus (T1DM). ISPAD recommend monitoring every five years and statin use to maintain LDL cholesterol <3.4 mmol/L1. Guidance is specific to LDL. NICE guidelines do no recommend routine screening for CYP with T1DM.Methodology: We reviewed all lipid profiles (including cholesterol, triglyce...

Background: Animal studies have demonstrated relationships between Vitamin D and glucose homeostasis. There is paucity of evidence examining the relationship between the glycemic control in children with Type 1 Diabetes Mellitus (T1DM) and vitamin D status.Objective: To determine the effects of vitamin D status on the glycemic control in children and adolescents with T1DM.Methods: Retrospective data were collected on 348 children a...

Background: Animal studies have demonstrated relationship between Vitamin D and glucose homeostasis. There is paucity of evidence examining the relationship between the glycemic control in children with type 1 diabetes mellitus (T1DM) and vitamin D status.Objective: To determine the effects of vitamin D status on the glycemic control in children and adolescents with T1DM.Methods: Retrospective data were collected on 348 children an...

Introduction: Early onset diabetes mellitus and poor glycaemic control can predispose to various long-term complications. NICE recommends regular assessment starting at 12 years of age to diagnose micro/macro vascular complications and neuropathy for appropriate management. Rare undiagnosed metabolic disorders could pose diagnostic and management challenges. We report an unusual presentation of a rare metabolic disorder in an adolescent with type-1 diabetes mellitus (T1D)....

Background: FreeStyle Libre flash glucose monitoring system (FSL) has recently gained popularity as it can potentially reduce the number of finger prick capillary blood glucose tests (CBG). Initial short-term studies in adults have demonstrated accuracy although there is no paediatric data available to date. We aimed to assess the accuracy of FSL in children and young people and evaluated the user experience in routine clinical practice.Methods: About 31...