Searchable abstracts of presentations at key conferences in endocrinology

ea0011p243 | Cytokines and growth factors | ECE2006

Molecular mechanisms of idiopathic muscle hypertrophy in humans

Solomon AM , Hoffman EP , Ghimbovschi SD , Wang Z , Orrell RW , Goldspink G , Harridge SD , Bouloux PMG

Understanding the molecular factors that regulate human muscle mass is acquiring increasing scientific interest. Hitherto, known (+ve) endocrine regulators of lean body mass included the GH-IGF-1 system, anabolic steroids, and (−ve) myostatin. In order to elucidate this process further, we have investigated a clinical case at a genetic and phenotypic level. A 46-year-old man with idiopathic muscle hypertrophy requiring multiple therapeutic fasciotomies underwent clinical...