Endocrine Abstracts

Abstract: Glomerular hyperfiltration has been suggested as a possible mechanism linking obesity and chronic kidney disease, independently of classical risk factors such as diabetes. In terms of determining the creatinine clearance has numerous drawbacks, in clinical use are predictors of glomerular filtration rate (GFR) which show varying degrees of accuracy in obese patients. The aim of our study was to determine whether it is in our group of obese patients without type 2 dia...

Introduction: Multiple endocrine neoplasia syndrome type 1 (MEN1) associated thymic carcinoids (Th-NETs) are rare and have poor prognosis. Cushing syndrome (CS) caused by Th-NET in MEN1 syndrome is extremely rare.Case report: We report a case of a 55-year-old man with CS at presentation due to ectopic ACTH production in MEN1 syndrome. Thirty years ago, this patient had total gastric resection due to Zollinger-Ellison’s syndrome and extirpation of tw...

Introduction: Women with polycystic ovary syndrome (PCOS) are at increased risk of developing insulin resistance (IR) and T2DM. In this study, we attempted to detect IR parameters that could be the best predictor T2DM in PCOS comparing to controls.Description of methods/design: In 130 women with PCOS (BMI=29.7±0.66 kg/m2; age: 25.6±0.59 years) and 41 controls (age and BMI matched) (BMI=28.5±1.35 kg/m2; age: 26.5±...

Bariatric surgery, especially malapsorptive procedures like gastric bypass, can lead to anaemia due to lack of iron absorption as well as vitamins essential for the normal functioning of the hematopoietic system.Methods: We have analysed changes in red blood cells (RBC), haemoglobin (Hb), white blood cells (WBC), serum iron (Fe), and vitamin B12 3 years after gastric bypass in 142 morbidly obese patients (female, n=108 and male, n=34). ...

Introduction: Obesity is a risk factor for the development of insulin resistance, type 2 diabetes, cardiovascular diseases and non-alcoholic fatty liver disease. The aim of our study was to examine predictive value of liver enzymes in assessing biomarkers of insulin sensitivity in obese, non-diabetic adults.Methods: 1104 obese, non-diabetic adults were included in the study. Patients were divided into two groups: Group A (BMI 30.0–39.9 kg/m2</s...

Introduction: Women with polycystic ovary syndrome (PCOS) are at increased risk of developing insulin resistance and type 2 diabetes mellitus (T2DM). The aim of this study was to detect insulin resistance parameters that could be the best predictor T2DM in PCOS when compared with healthy women.Methods: This study include 114 PCOS women (BMI: 29.2±0.60 kg/m2; age: 25.3±0.57 years) and 41 controls (age- and BMI-matched) healthy women (...

Introduction: FRAX score is the ten-year estimated risk calculation tool for bone fracture which includes clinical data and hip bone mineral density measured by x-ray densitometry (DXA). The aim of the study was to elucidate the ability of the FRAX score in discriminating between bone fracture positive and negative postmenopausal women with subclinical hyperthyroidism.Material and methods: FRAX score calculation were performed in 27 postmenopausal women ...

Introduction: Obesity is associated with high risk for coronary artery disease, high blood pressure, elevated serum cholesterol level, malignancy and Type 2 diabetes mellitus. After weight loss, especially after bariatric surgery there is improvement in blood pressure, metabolic parameters and ventilatory anaerobic threshold.Material and methods: Ergospirometry (Shiller CS-200, Bruce protocol) was performed in 50 obese patients before and six months afte...