Searchable abstracts of presentations at key conferences in endocrinology

ea0036oc7.5 | Oral Communications 7 | BSPED2014

The relationship of vibration perception threshold with metabolic control and duration of disease in British children with type 1 diabetes

Kallampallil Jins , Goodwin Simon , Riddle Miles

Introduction: Type 1 diabetes affects a large number of children and adolescents, and its incidence is on the rise worldwide. The most devastating and important consequence of diabetes is its role in the development of long-term microvascular complications. This study aimed to study the role of the non-invasive vibration perception threshold (VPT) test in detecting subclinical peripheral neuropathy, and its correlation with metabolic control and duration of disease in British ...

ea0049ep83 | Adrenal cortex (to include Cushing's) | ECE2017

A near miss on blaming the heart: a rare case of Adrenocortical carcinoma with thrombus extension into right atrium and Cushing syndrome

Morsi Hadeil , Eisa Mohamed , Goodwin Lynsey , Flegg Peter , Aye Myint

A 39 year old female patient presented with one week history of Shortness of breathing. Over the last four months she noted bilateral leg swelling, which failed to improve on diuretic. Examination revealed no other evidence of fluid overload or heart failure. An element of right heart strain rather than failure was raised on cardiologists review. Subsequently, an echo showed a friable mass extending form inferior vena cava to right atrium into proximal left ventricle. The natu...

ea0011p392 | Diabetes, metabolism and cardiovascular | ECE2006

Testosterone replacement therapy reduces insulin resistance, and improves glycaemic control in hypogonadal men with Type 2 diabetes

Kapoor D , Goodwin E , Channer KS , Jones TH

Type 2 diabetes mellitus is associated with increased prevalence of low serum testosterone levels in men [1]. Testosterone levels in men are known to be positively correlated with insulin sensitivity and negatively with visceral obesity. We performed a double blind placebo controlled crossover study to determine the effect of testosterone treatment on insulin resistance and glycaemic control in 24 hypogonadal men (10 patients treated with insulin) above age of 30 with Type 2 d...

ea0009p2 | Diabetes and metabolism | BES2005

Rosiglitazone increases testosterone levels in hypogonadal men with Type 2 diabetes

Kapoor D , Goodwin E , Channer K , Jones T

Type 2 diabetes mellitus is associated with increased incidence of low serum testosterone levels in men. Testosterone is known to be positively correlated with insulin sensitivity. Rosiglitazone is an insulin sensitizing agent that reduces insulin resistance by binding to PPAR gamma receptor. The purpose of this study was to determine the effect of Rosiglitazone on testosterone levels in hypogonadal men with Type 2 diabetes.This study was approved by BDG...

ea0003s23 | Metalloproteinases and Their Inhibitors: Regulators of Endocrine Activity | BES2002

Matrix metalloproteinases, cytokines and bone/cartilage remodelling

Maciewicz R , Bowyer J , Brownrigg N , Goodwin L , Pickford R , Tessier J , Waterton J , Westwood R

In arthritides, such as osteoarthritis (OA), there is considerable bone and cartilage remodelling associated with the disease progression. The destruction of these tissues is responsible for the pain and disability associated with the disease. Metalloproteinases (MPs) are thought to contribute to this process but as yet this remains unproven in the clinic.The objective of this study was to elucidate the role of the specific MPs, aggrecanase and collagen...

ea0098c12 | Clinical – Chemo/SSA/Biologics | NANETS2023

Real world use of virtual care for treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

J Phillips William , Pradier Michelle , Goodwin Rachel , Vickers Michael , Asmis Tim

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a relatively rare group of tumors. Traditionally, management of unresectable GEP-NETs was performed by in-person assessment at specialized regional cancer centers. The COVID-19 pandemic resulted in an unprecedent shift towards virtual care. The aim of this study is to evaluate the use of virtual care for GEP-NETs after the COVID-19 pandemic at a high-volume academic cancer center. Me...