Searchable abstracts of presentations at key conferences in endocrinology

ea0011p361 | Diabetes, metabolism and cardiovascular | ECE2006

Insulin receptoropathies are distinguished from other syndromes of severe insulin resistance by elevated plasma adiponectin levels

Semple RK , Soos MA , Mitchell CM , Wilson JC , Luan J , Cochran EK , Wareham NJ , Gorden P , Chatterjee VKK , O’Rahilly S

Leptin and adiponectin are cytokine-like hormones secreted by white adipose tissue. Plasma leptin correlates closely with total body fat mass, and its secretion is positively regulated by insulin in vivo and in vitro. Hypoleptinaemia is a key centrally-mediated orexigenic stimulus. Plasma adiponectin, in contrast, correlates negatively with whole body fat mass and insulin resistance in adults, and its expression is regulated negatively by insulin in vivo a...

ea0065p57 | Adrenal and Cardiovascular | SFEBES2019

A case of familial hyperkalemia due to Gordon’s syndrome

Rathi Manjusha

Gordon’s syndrome is a rare, autosomal dominant disorder characterized by hyperkalaemia, hypertension, mild hyperchloraemic metabolic acidosis despite normal glomerular filtration rate, with low or low-normal plasma renin activity and aldosterone concentrations. Here we describe a case of Gordon’s syndrome presenting a diagnostic challenge. She first presented age 17 yrs with constipation and abdominal pain. No significant past medical or medication history to note. ...

ea0025s3.2 | Fat endocrinology: disorders of adipose tissue and lipids important to the endocrinologist | SFEBES2011

Familial partial lipodystrophy: an introduction and the importance of diagnosing FPLD

Suliman S

Lipodystrophy including familial, acquired and secondary forms displays the full spectrum of the metabolic syndrome including severe insulin resistance, hyperinsulinaemia; hypertension, hypertriglyceridaemia, low HDL cholesterol, and hyperglycaemia1. This group have an absolute or partial reduction in fat mass, yet often show more extreme metabolic features than obese individuals.Partial lipodystrophy may be genetic or acquired. Genetic causes...