Endocrine Abstracts

Introduction: Parathyroid carcinoma is a rare endocrine malignancy accounting for <1% of all cases of hyperparathyroidism. Diagnosis and treatment is still difficult.Case report: A 32-year-old women was admitted to the hospital because of mental status changes, polyuria, polydipsia, musculoskeletal pain and weight loss (34 kg during last year). She had history of nephrolithiasis, pancreatitis, cholelithiasis, peptic ulcer disease, osteoporosis and di...

Introduction: Ectopic release of ACTH caused by pheochromocytoma is extremely rare. The clinical picture of hypercortisolism is overlapped by catecholamine excess that makes diagnosis more difficult.Case report: A 74-year-old women was admitted to the hospital because of hypertension, recently diagnosed diabetes and weight loss (10 kg per six months). In physical examination: cachexia, dehydratation, pallor, hirsutism, proximal muscle weakness, elevated ...

Introduction: The mixed tumor which secretes an excess of both GH and TSH causing acromegaly and hyperthyroidism is rare. The main problem is the late diagnosis, especially in men, even 10 years after the occurrence of the first symptoms.Case report: A 53-year-old men, was admitted to the our department, with complaints of excessive sweating and enlargement of the hands. His medical history included arterial hypertension. Past medical history revealed th...

Introduction: Assessment of the RAAS has been recently granted a much greater role in the evaluation of patients with arterial hypertension (AH). There is no single test efficient in selection of patients for second-step etiological investigation.Methods: 198 consecutive patients- 119 women (60%) and 79 men (40%)- hospitalized in years 2009-2011 at the Clinical Department of Endocrinology UMB as to diagnose PA. In each patient PRA and PAC (basic and afte...

Apoptosis plays a pivotal role in the regulation of the immune mechanisms in the pathogenesis of autoimmune thyroid diseases. The aim of the study was to compare soluble Fas, FasL and Bcl-2 in Graves’ disease (GD) and Hashimoto thyroiditis (HT) in relation to the age of the studied patients. The study was carried out in 5 groups of subjects: 1/14 patients with GD in euthyreosis on methimazol (euGD) 2/20 patients with hyperthyroid GD (hrGD) 3/15 patients with HT in euthyre...

Background: Significant prevalence of hypertension in the world’s population and its consequences tend to an intensive search for pathogenesis and etiology of this disease. Epidemic of hypertension is accompanied by an epidemic of adrenal incidentaloma and grows in direct proportion to patients age. Polymorphism of aldosterone synthase (CYP11B2) in -344th region of promoter seems to have much in common with hypertension and adrenal incidentaloma.Aim...

Introduction: Nowadays is believed that primary aldosteronism (PA) is the most frequent cause of secondary hypertension and reaches 10% of whole hypertensive population. The activity of the mineralocorticoid hormone may be change by polymorphism of aldosterone synthase gene (CYP11B2) e.g. in promoter -344T/C region. Aim of this study was to find differences in baseline plasma aldosterone concentration (PAC), plasma renin activity (PRA), aldosterone – renin ratio (ARR) and...

Introduction: We report a case of CAH who developed several complications due to poor control. Proper diagnosis and treatment can enable men with the disease to have a normal life and fertility. Case report 39-year-old patient with a history of primary adrenal insufficiency was admitted to our department because of infertility. Semen analysis performed prior to hospitalization showed azoospermia. The patient did not have medical documentation regarding his disease and was not ...

It was shown recently that orbital fibroblasts express intensively CD40 and its ligation stimulates proinflammatory cytokines, glicosoaminoglycans and PGE2 production. CD40/CD154 interaction in the pathogenesis of Graves’ orbitopathy (GO) is suggested an important pathway of T cells induced fibroblast activation and proliferation.Aim: To assess the role of CD40/CD154 interaction in GO pathogenesis and to estimate usefulness of soluble CD4...

Iatrogenic Cushing syndrome caused by the use of steroid medications is common because of the widespread use of these medications for the treatment of many diseases, however development of Cushing syndrome from the topical corticosteroids is very rare in adults.A 45-year-old men (BMI: 44 kg/m2), with a history of psoriasis, developed manifestations of Cushing syndrome, which included weight gain, central obesity, moon face, facial plethora, bu...