Endocrine Abstracts

Objective: To assess the sensitivity of granins – chromogranin A (CgA), secretogranin II (SgII), and secretoneurin (Sn) as biochemical and immunohistochemical markers of non-functioning pituitary adenomas (NFPAs):Methods: 50 patients with NFPAs were included in the study. Tissue samples were immunostained for pituitary hormones, Ki-67, αSU, CgA, SgII, and Sn. Furthermore, we have determined the levels of CgA, SgII in the serum and Sn in the pla...

We present a case of 32-year old male patient who was admitted to hospital because of newly discovered hypertension with symptoms of 4P (pain, pallor, perspiration and palpitation). During hospitalization the patient presented with polyuria, polydipsia, hyperglycemia and psychotic disorders. The suspicion of secondary hypertension was made.Catecholamine examination test was done and revealed very high levels of adrenalin (five times more than normal), no...

Background: Chromogranin A (CgA) belongs to the family of granins, proteins which are an integral part of the secretory granules of neuroendocrine cells in endocrine glands and the diffuse neuroendocrine system. While it has become standard clinical practice to measure serum CgA in neuroendocrine tumors, various other non-endocrine conditions may increase this marker’s concentration and lead to diagnostic problems.Case report: We present the case of...

Introduction: Chromogranin A (CgA) is a major representative of the protein family named granins stored predominately in secretory granules of the diffuse neuroendocrine system. Circulating CgA serves as a biomarker of neuroendocrine tumors (NETs), but its increased plasma concentration is present in various cardiovascular, gastrointestinal, renal and inflammatory diseases. Intra-granular and/or extracellular proteolysis of CgA generates a variety of biologically active fragme...

Background: Calcinosis cutis is a rare manifestation characterized by calcium deposits in the skin and subcutaneous tissues, mostly found in auto-immune diseases. A case of calcinosis cutis (on the vertex and the face) associated to hyperparathyroidism is presented. We discuss the etiology, diagnosis and management of this rare condition, along with a short review of the literatureCase presentation: We report a case of calcinosis cutis with primary hyper...

BackgroundTo examine the secular trends of dietary food groups and diet quality among adults, overall and by sex, education, and occupation status.MethodsThis study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS). Demographic and anthropometric measurements were gathered using standard questionnaires. In terms of socioeconomic information, participants were divided into two gro...

Armour thyroid is desiccated porcine extract which is a historical treatment for hypothyroidism. It contains both L-thyroxine and liothyronine. Each grain (60 mg) contains 38 μg of L-thyroxine and 9 μg liothyronine. Since the 1960’s its use has been superseded by L-thyroxine. Due to limited clinical effectiveness studies, it is not licensed for use in the United Kingdom. We present a case of Armour thyroid use in preg...

Developmental exposure to endocrine-disrupting compounds may adversely affect female reproductive physiology. The present study investigated the effect of Pirimiphos-methyl (PM), an organophosphate pesticide, widely used to protect crops and grains against pests, on puberty onset in female rats. Female weanling rats were orally treated with 20 mg/kg and 40 mg/kg of PM for ten consecutive days from postnatal day 22 to 31. Following vagina opening and attainment of estrus and di...

Aim: Auger electron (AE)-emitting radionuclides are well suited as molecularly targeted radionuclide therapeutics (MRT) due to the high energy deposition density in the immediate vicinity of the decay site which avoids to a large extent non-specific radiotoxicity. However, due to the short range of the low-energy Auger (and Coster-Kronig) electrons, it is imperative that the AE emitting agent is closely associated with the cell nucleus. In this study we evaluate the dose depos...

Selenium is an essential element for humans. Important dietary sources of selenium include meat, seafood, and grains. Selenium is incorporated into a range of selenoenzymes with antioxidant properties. Being crucial for the activity of the deiodinase enzymes, selenium is especially important for the synthesis and metabolism of thyroid hormones. Selenium in relation to thyroid diseases has been widely explored. Epidemiological studies have shown that a low selenium status is as...