Endocrine Abstracts

Aims: Hiponatremia is the most frequent electrolyte disturbance. Our aim is to retrospectively analyze the diagnosis of hyponatremia in the discharge sheets of a tertiary hospital during 5 yearsMethod: Data from the MBDS (Minimum Basic Data Set) of the discharged patients from the Hospital Clínico San Carlos (Madrid) between the years 2005 and 2009 was analysed. The 5th Edition of the ICD-9-CM was used for the codification of the diagnoses and proce...

The function of the thyroid gland is to maintain thyroid hormone (TH) levels in the blood circulation. Thyroid epithelial cells liberate TH from the precursor molecule thyroglobulin (Tg) by the combined proteolytic action of the cathepsin B, K, L, and S. Cathepsin L-deficiency in mice results in impaired processing of Tg and remnants of dead cells in the follicle lumen. Recently, we have shown that Trace amine-associated receptor 1 (Taar1) is localized on the primary cilia of ...

3-Iodothyronamine (T1AM) is a novel endogenous derivative of thyroid hormone (TH), recently described by Scanlan et al. (Nat. Med. 10: 638, 2004). In vitro, T1AM can stimulate the production of cAMP via activation of a heterologously expressed G protein-coupled receptor (GPCR) now referred to as trace amine-associated receptor 1 (TAAR1; Lindemann et al. Genomics 85: 372, 2005). In adult, unanesthetized C57Bl6/J mice, T1AM produces prof...

Background: The increase of global childhood obesity has led to an increase of associated co-morbidities also at a young age. The pro-inflammatory state and insulin resistance are two master regulators of several complications, including hypertension and pre-diabetes frequently connected in a complex cross-talk.Aim: To evaluate the relationship between glucose alterations and blood pressure and the pathogenetic involvement of the renin-aldosterone system...

Background: Approximately 20% of NET patients develop CS, characterised by diarrhoea and flushing. However, CS is not the only cause of diarrhoea among NET patients. Non-CS causes should be considered to allow for appropriate management. We investigated the reported occurrence of diarrhoea from various non-CS causes in patients with gastroenteropancreatic NETs (GEP-NETs), to explore the need for differential diagnosis (DDx) of NET diarrhoea.Methods: MEDL...

Aim: Multidisciplinary approach is mandatory in the management of endocrine tumors. Herein, we summarize the healthcare activity performed during the last 6 years at the multidisciplinary committee for endocrine tumors of a tertiary and University Hospital.Methods: A search of clinical-care activity of the endocrine tumors committee of our hospital from 2011 to 2016 was performed. Clinical and demographic data of all patients were recorded. The committee...

GH deficiency (GHD) in adults is characterized by a tendency towards fat mass gain and may predispose to type 2 diabetes mellitus.GH replacement (GHR) is associated with impaired insulin sensitivity shortly after starting therapy, reflected by increased fasting glucose and insulin levels. Available evidence suggests that concerns regarding glucose intolerance in patients receiving long-term GHR have not been substantiated. However, several environmental and lifestyle-related f...

PRRT is a treatment choice for inoperable or metastasized neuroendocrine tumours and this therapy seems more effective in the biochemical and volume control of disease than SSA. We investigated the role of medical therapy with SSA and PRRT in patients with well and moderately differentiated neuroendocrine tumours. We evaluated 55 patients with well or moderately differentiated neuroendocrine tumours; 31 patients with either metastatic, unresectable or functioning tumours were ...

Type II diabetes is a clinical disorder of glucose and fat metabolism, caused by an inability of insulin to promote sufficient glucose uptake into adipose tissue and striated muscle and to prevent glucose output from the liver. Skeletal muscle is an important element for the maintenance of glucose homeostasis because it can increase, after stimulation, glucose uptake from the blood. In previous experiments we found that acylated ghrelin (AG), unacylated ghrelin (UAG), obestati...

A 16-years-old male, with familiar precedents of familiar macrocephaly, he has been visited in external consultations of digestive in 2008 because he had rectal bleedings. A colonoscopy was made two times, in those situations some intestinal polyps have been extirpated. The result of the pathological antomy was polyps ganglioneuromas.Due to the pathological compatible anatomy with ganglioneuromas, it stemmed to external consultations of endocrinology to ...