Searchable abstracts of presentations at key conferences in endocrinology

ea0078OC9.2 | Oral Communications 9 | BSPED2021

Sex steroid priming for growth hormone stimulation testing – a systematic review

Duncan Gregor , Mitchell Rod

Background: Growth hormone stimulation testing (GHST) is used to diagnose growth hormone deficiency (GHD) in children. Given that sex steroids impact on anterior pituitary function, there is concern around the efficacy of GH stimulation testing in pre/peripubertal children, where sex steroid levels are low. Sex steroid priming prior to GH stimulation testing is thought to improve test efficacy in these children, however evidence to support its use in clinical practice is limit...

ea0021s8.3 | Role of the circadian clock in endocrinology | SFEBES2009

The adrenal clock: impact on adrenal steroidogenesis

Kiessling Silke , Eichele Gregor , Oster Henrik

In mammals, a master pacemaker residing in the hypothalamic suprachiasmatic nuclei (SCN) and subordinate clocks found throughout the body coordinate circadian rhythms of behavior and physiology. One prominent physiological rhythm is the release of glucocorticoids (GCs) by the adrenal gland, brought about by the rhythmic activation of the hypothalamus–pituitary–adrenal (hpa) axis and the secretion of ACTH from the pituitary. In humans, blood GC levels peak in the earl...

ea0063p504 | Calcium and Bone 2 | ECE2019

Effect of zoledronic acid on trabecular bone score and other markers of bone health in heart transplanted patients

Rakusa Matej , Vrtovec Bojan , Poglajen Gregor , Jensterle Sever Mojca

Objective: Trabecular bone score (TBS) is associated with an increased risk of prevalent and incident fractures. It has a role of fracture assessment in secondary osteoporosis related to diabetes, acromegaly and hyperparathyroidism and in glucocorticoid-induced osteoporosis. However, it is understudied as a marker of bone health in heart transplanted patients. The aim of our pilot study was to evaluate the effects of zoledronic acid (ZA) on bone health including TBS in this po...

ea0041ep715 | Male Reproduction | ECE2016

Association between low testosterone and graft dysfunction early after heart transplantation: results from cross-sectional study

Poglajen Gregor , Jensterle Mojca , Janez Andrej , Vrtovec Bojan

Introduction: An inverse relation was found between testosterone and vasculopathy of the allograft in heart-transplanted men. We evaluated the correlation between serum testosterone levels and graft function early after heart transplantation.Methods: In a cross-sectional study serum total testosterone levels prior to hospital discharge (19±3 postoperative day) was determined in 49 consecutive male patients who underwent heart transplantation between...

ea0016s20.2 | Translational highlights | ECE2008

SF-1 knockout mice as a model for hormone independent brain sexual differentiation

Spanic Tanja , Budefeld Tomaz , Grgurevic Neza , Tobet Stuart , Majdic Gregor

Animals that are not exposed to endogenous sex steroids during development provide an important model for studying hormone independent development of brain sex differences. Due to gonadal agenesis, male and female steroidogenic factor 1 knockout (SF-1 KO) mice are born phenotypically female. Normally, they die shortly after birth due to adrenal insufficiency. Early corticosteroid injections followed by adrenal transplantation can maintain SF-1 KO mice into adulthood. As severa...

ea0041ep777 | Obesity | ECE2016

A prostate cancer risk associated polymorphism regulates androgen mediated regulation of a novel long noncoding RNA, IRX4lncRNA

Panchadsaram Janaththani , Tevz Gregor , Stylianou Nataly , Hollier Brett , Nelson Colleen , Williams Elizabeth , Clements Judith , Batra Jyotsna

Prostate cancer (PCa) is the second most common cause of cancer death in developed countries. Our RNAseq analysis identified a novel long non-coding RNA, IRX4lncRNA at chromosome 5p15. The expression of IRX4lncRNA was much higher in prostate tumor samples (n=50) compared to their matched controls. Moreover, knockdown of lncRNA reduced the cell proliferation of LNCaP cells and this lncRNA was down-regulated in the cells undergoing Epithelial ...

ea0042p7 | (1) | Androgens2016

μ-Crystalline as hormone antagonist in prostate cancer

Merkel Olaf , Aksoy Osman , Suzani Martin , Hassler Melanie , Schlangen Karin , Balber Theresa , Mitterhauser Markus , Moazzami Ali , Schlederer Michaela , Turner Suzanne , Egger Gerda , Hormann Gregor , Hacker Markus , Culig Zoran , Pencik Jan , Kenner Lukas

Prostate cancer (PCa) is the most frequent cancer in men in the western world. PCa growth is highly dependent on androgens and androgen ablation is the cornerstone of current therapeutic approaches. μ-Crystalline (CRYM) is the main component of the kangaroohs eye’s lens. CRYM binds thyroid hormone (T3) in a NADPH dependent manner thereby sequestering it from being transcriptionally active in the nucleus. The role of CRYM in prostate cancer is largely unknown. This st...