Searchable abstracts of presentations at key conferences in endocrinology

ea0011p909 | Thyroid | ECE2006

The thyroid gland and its selenoenzymes are preferentially supplied in selenium-deficient transgenic mice

Schomburg L , Riese C , Michaelis M , Griebert E , Klein MO , Sapin R , Schweizer U , Koehrle J

Selenium (Se) is indispensable for enzymatic activities of glutathione peroxidases (GPx) involved in antioxidative defense and deiodinase isozymes (Dio) that control thyroid hormone (TH) action. Se deficiency can impact negatively on thyroid galnd funtioning and TH metabolism and thereby perturb development and metabolism. We have generated Se-deficient mice by genetic inactivation of Selenoprotein P (SePP), the main plasma Se carrier. SePP-KO mice display decreased serum and ...