Searchable abstracts of presentations at key conferences in endocrinology

ea0011p217 | Comparative endocrinology | ECE2006

Ontogeny of galanin and vasotocin immunoreactivity in the supraoptic nucleus (SON) and the bed nucleus of the stria terminalis (BSTM) in chickens

Klein S , Grossmann R

Vasotocin (AVT), the avian homolog of vasopressin, is synthesized in the BSTM of chickens in addition to the hypothalamo hypophysial axis. In previous reports, sex specific AVT–immunoreactivity(ir) in male BSTM (Jurkevich et al. 1999) and it’s ontogeny were demonstrated (Grossmann et al. 2002). In addition, galanin (Gal) was found in male BSTM co-localized to AVT. In the present study, the ontogeny of AVT- and Gal-ir was investigated in the SON as part ...

ea0016p604 | Reproduction | ECE2008

Age-adjusted variations in dynamics of the follicular growth in relation to ovarian steroid hormones in the domestic hen

Lebedeva Irina , Lebedev Vladimir , Grossmann Roland , Parvizi Nahid

In birds similar to mammalian species, the reproductive performance in females deteriorates with age. In the present study, relationships between the growth of preovulatory follicles (PF), reproductive aging and sex steroids were investigated using young hens with long clutch (YLC), old hens with long clutch (OLC) and old hens with short clutch (OSC). 1) hens were killed 1.5 and 14.5 h after assumed ovulation. 2) YLC hens were killed 3.5 h after treatments with LH and/or amino...

ea0059oc6.1 | Neuroendocrinology and Reproduction | SFEBES2018

A controlled cross-sectional study of bone microarchitecture in transgender individuals

Zajac Jeffrey D , Bretherton Ingrid , McFarlane Thomas , Spanos Cassandra , Grossmann Mathis , Cheung Ada S

Sex steroids have complex effects: testosterone predominantly regulates trabecular and estradiol, cortical bone1. Studies in transgender individuals use insensitive technology and report conflicting effects2. We hypothesized estradiol therapy will increase cortical volumetric bone mineral density (vBMD) in male-to-female (MtF) individuals and testosterone therapy will increase trabecular vBMD in female-to-male (FtM) individuals.Aims...

ea0034p348 | Steroids | SFEBES2014

The effect of green tea extracts on steroidogenesis, proliferation and apoptosis in ovarian granulosa cells

Kadasi Attila , Maruniakova Nora , Kolesarova Adriana , Stochmalova Aneta , Alexa Richard , Grossmann Roland , Sirotkin Alexander V

The aim of our study was to examine the influence of green tea molecules on basic ovarian functions. For this purpose we have examine the effect of green tea extract, fraction of antioxidants (GTAO) and green tea fraction of polyphenols (GTPP) (at the doses 0, 1, 10, and 100 μg/ml) on proliferation, apoptosis, and steroidogenesis by cultured porcine ovarian granulosa cells. Markers of proliferation (PCNA) and apoptosis (bax) were detected by immunocytochemistry. Secretion...

ea0028p262 | Pituitary | SFEBES2012

Quality of life in patients with non-functioning pituitary adenoma: the Oxford experience

Capatina Cristina , Christodoulides Constantinos , Fernandez Alberto , Grossmann Ashley , Wass John , Karavitaki Niki

Data on the quality of life (QoL) of patients with non-functioning pituitary adenoma (NFA) are sparse and conflicting. We have therefore evaluated the QoL in patients with NFAs followed-up in a tertiary UK referral centre and explored the impact of various factors. Three validated questionnaires (Short Form 36-SF36, Nottingham Health Profile-NHP and European Quality of Life Scale-EuroQoL) were offered to consecutive NFA subjects attending outpatient clinics over a 6-month peri...

ea0026p119 | Female reproduction | ECE2011

The role of metabolic hormones ghrelin, leptin and obestatin in control of ovarian functions

Sirotkin Alexander , Meszarosova Monika , Grossmann Roland , Korzhenevskaja Marina , Benco Andrej , Pavlova Silvia

The recent original data concerning interrelationships between metabolic hormones (ghrelin, leptin, obestatin) and feeding, action of metabolic hormones on basic ovarian functions (proliferation, apoptosis, secretory activity, response to gonadotropins, oocyte maturation) and intracellular mechanisms of its action in different species (rabbit, pig, human, chicken) are reviewed. It was shown, that metabolic hormones ghrelin, leptin and obestatin can control proliferation, apopt...

ea0031p302 | Pituitary | SFEBES2013

Effect of t-2 toxin and combination of t-2 toxin with resveratrol and mc2183 on ovarian cells of japanese quails

Maruniakova Nora , Kadasi Attila , Medvedova Marina , Halenar Marek , Bulla Jozef , Sirotkin Alexander V , Grossmann Roland , Kolesarova Adriana

Occurence of mycotoxins in various food and feed commodities is a worldwide problem. T-2 toxin is one of the most toxic trichothecene mycotoxin, produced mainly by Fusarium species. Poultry belongs to very sensitive species which are very often explored to toxic effects of mycotoxins. The aim of our in vitro studies was to examine secretion activity of ovarian granulossa cells to produce progesterone P4 after T-2 toxin and its combinations with res...

ea0041ep607 | Endocrine tumours and neoplasia | ECE2016

Glucagon-like-1 Receptor imaging specifically localizes insulinomas in patients with Multiple Endocrine Neoplasia Type 1 (MEN-1)

Antwi Kwadwo , Fani Melpomeni , Heye Tobias , Nicolas Guillaume , Merkle Elmar , Pattou Francois , Grossmann Ashley , Chanson Philippe , Reubi Jean Claude , Gloor Beat , Wild Damian , Christ Emanuel

Introduction: Surgery is often the only treatment option that can effectively treat patients with insulinoma in MEN-1. However, the surgical intervention should be limited as surgery can not cure patients with MEN-1. It is, therefore, mandatory to correctly localize insulin secreting tumors from other neuroendocrine tumors.Materials and Methods: In this report we include 6 patients with proven endogenous hyperinsulinemic hypoglycemia and neuroglycopenia ...

ea0059p011 | Adrenal and steroids | SFEBES2018

Androgen deprivation therapy causes selective loss of levator ani and leg muscle volumes

Zajac Jeffrey D , Cheung Ada S , Ly Vivian , Cunningham Christopher , Ko Dong-Kyoon , Gray Hans , Hoermann Rudolf , Strauss Boyd J G , Hassan Ebrahim Bani , Duque Gustavo , Pandy Marcus G , Grossmann Mathis

Background: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a global loss of lean mass. ADT leads to sexual dysfunction and a selective loss of leg muscle function, however individual muscle volumes have never been evaluated. We aimed to assess in men undergoing ADT, the muscle volumes of levator ani, which in mice is androgen-responsive, and of lower-limb muscles.Methods: We conducted a prospective case-control study involving 34 m...