Searchable abstracts of presentations at key conferences in endocrinology

ea0042p34 | (1) | Androgens2016

Mechanisms of radioresistance in prostate cells

Guggenberger Fabian , Erb Holger , Skvortsova Ira-Ida , Culig Zoran , Santer Frederic R.

Among androgen deprivation therapy (ADT), radiation therapy is an approved treatment either for early stage local PCa, but also for metastatic M1 stage PCa. However, tumour relapse is a frequent event that affects about 80% of patients undergoing prior treatment. There is increasing evidence that the occurrence of cancer stem cells (CSC) may play an important role in therapy resistance, in particular also in radioresistance. However, our knowledge on the mechanisms of radiores...

ea0011s75 | Green over-the-counter endocrinology | ECE2006

Regulation of steroid receptor expression and proliferation in prostate cancer by genistein and other flavonoids

Bektic J , Guggenberger R , Schäfer G , Bartsch G , Klocker H

A diet rich in phytoestrogens such as flavonoids has been attributed as one of the reasons for the low incidence of prostate cancer in Asia as opposed to Western countries with a diet rich in fat and meat and the highest incidences of this cancer. In many cellular models of prostate cancer these substances, the prototype of which is genistein, inhibit cell proliferation and cell cycle progression and enhance the rate of apoptosis. The molecular mechanisms involve modulation of...