Endocrine Abstracts

In terms of mechanism by which thyroid diseases lead the endothelial dysfunction, several aspects have been taking into consideration. One potential factor may be variation in plasma asymmetric dimethylarginine (ADMA) levels. ADMA, which is derived from the catabolism of proteins containing methylated arginine residues, competitively inhibits NOS. The relationship between thyroid disease and variation in plasma ADMA levels is still a potential research area. The aim of this st...

Diabetes is an important risk factor for ischemic stroke. Hyperglycemia observed in acute ischemic stroke is accepted as a poor prognostic factor. In the present study, our aim is to investigate the effect of diabetes on the duration and cost of treatment in acute ischemic stroke.Three hundred sixty two acute ischemic stroke patients that were hospitalized in the university neurology clinic in 2015 were retrospectively evaluated. Patients that have diabe...

Diabetes that is an important risk factor for ischemic stroke should also be well-treated in acute ischemic stroke patients for the secondary prevention against the next strokes. In the present study, we investigated the rate of the treatment changes in diabetic acute ischemic stroke patients during their stay at hospital.One hundred twelve acute diabetic ischemic stroke patients that were hospitalized in the university neurology clinic were retrospectiv...

Pseudoacromegaly is a rare disorder characterized by cutaneous manifestations of growth hormone excess but with normal growth hormone levels or IGF-1. This condition described in patients with insulin resistance, hypothyroidism, pachydermoperiostitis and drug intake such as minoxidil. The hyperinsulinaemia impaired metabolic signalling may activate intact mitogenic signalling pathways and stimulate pathological tissue growth.A 41-year-old man presented w...

Introduction: In this study, we aimed to evaluate the effects of fat distribution and some adipokines on insulin resistance (IR) in prediabetic patients.Materials and Methods: cases were divided into three groups according to 75 gr-oral glucose tolerance test (OGTT) results [27 cases impaired fasting glucose (IFG), 36 cases impaired glucose tolerance (IGT) and 24 healthy control subjects]. Serum fasting insulin levels and lipid parameters were measured. ...

Aim: Hypocalcemia is a common problem after parathyroidectomy but is generally transient. In some cases the postoperative hypocalcemia is severe and prolonged despite normal or even elevated levels of parathyroid hormone (PTH). This phenomenon, called the hungry bone syndrome (HBS), occurs due to sudden withdrawal of PTH leading to a marked net increase in bone uptake of Ca, P, and Mg. We aimed to evaluate predictive factors for HBS development after parathyroidectomy.<p c...

Aim: The aim of this study was to investigate the relationship between the clinical and laboratory findings of metabolic bone disease regarding the levels of osteoprotegerin (OPG) and the receptor activator of nuclear factor kappa B ligand (RANKL) in the patients with diabetic nephropathy.Material and method: This study includes 61 type 2 diabetic patients and age-, sex-matched 20 healthy subjects. Diabetic patients were divided into three groups accordi...

Introduction: Indirect calorimetry is the most frequently used method to measure resting energy expenditure (REE), but the great expense of equipment precludes its widespread use. The best known REE calculation formula is the ‘Harris and Benedict Formula’. The aim of this study is to assess the impact of glucose metabolism status on REE.Methods: Data from 110 subjects with impaired glucose tolerance (IGT), 108 subjects with impaired fasting glu...

Diabetes mellitus (DM) includes a group of carbohydrate metabolism disorders that is characterized by hyperglycemia and leads long-term macro- and microvascular complications. Also siblings of type 2 diabetic patients have increased relative risk of micro and macrovasculer outcome of DM even though their plasma glucose levels in normal range. Genetically determined hyperinsulinemia, insulin resistance and associated dyslipidemia have crucial role in the processes of vascular a...

Accelerated coronary and peripheral vascular atherosclerosis is one of the most common and chronic complications of diabetes mellitus. A relatively recently analysed aspect of coronary artery disease in this condition is its silent nature. We studied silent myocardial ischaemia (SMI) in unselected consecutive middle aged asymptomatic patients with type II diabetes by treadmill exercise test.Ninety four asymptomatic type II diabetics between the ages 36 a...