Searchable abstracts of presentations at key conferences in endocrinology

ea0044ep75 | (1) | SFEBES2016

The challenges to diagnose and differentiate TSHoma from thyroid hormone resistance: a case report

Hamdan Khaliq , Koulouri Olympia , Gurnell Mark , Chatterjee Krishna , Owen Penelope

TSHoma is rare, with an incidence of 1 per million, and <1% of all pituitary tumours. We reported a case involving a 49-year-old female who was first referred to our endocrine unit in 2006 with excessive lethargy and abnormal TFT’s. She was thought to have thyroid hormone resistance for several years until 2015 when she reported having persistent symptoms and further investigation suggested an alternative diagnosis.Results: Ft4=41.6 pmol/l, TSH=...

ea0050s7.1 | Taking a risk on love - the endocrinology of behaviour | SFEBES2017

Risky business – when endocrinology takes over…

Gurnell Mark

The financial markets represent the largest and most intense competitive forum ever constructed. Here, according to classical economic theory, competition drives optimal allocation of capital to projects with the highest returns, thereby promoting global prosperity. However, financial markets can be volatile, cycling between ‘bull’ and ‘bear’ states, and threatening the stability of the global economy.Bull markets can morph into bubbl...

ea0050s7.1 | Taking a risk on love - the endocrinology of behaviour | SFEBES2017

Risky business – when endocrinology takes over…

Gurnell Mark

The financial markets represent the largest and most intense competitive forum ever constructed. Here, according to classical economic theory, competition drives optimal allocation of capital to projects with the highest returns, thereby promoting global prosperity. However, financial markets can be volatile, cycling between ‘bull’ and ‘bear’ states, and threatening the stability of the global economy.Bull markets can morph into bubbl...

ea0038mte4 | (1) | SFEBES2015

Investigation and management of TSHoma

Gurnell Mark

Background: Thyrotropinomas (TSHomas) have traditionally been considered a rare, albeit important cause of thyrotoxicosis. However, a recent report suggests their prevalence may be 2–3 times higher than previously suspected. In addition, although early case series described a predominance of invasive macroadenomas, recent findings (including in our own cohort of 40 patients) confirm that microadenomas are being increasingly diagnosed, and the clinical/biochemical phenotyp...

ea0035s26.2 | Pitfalls in hormone measurement | ECE2014

Pitfalls in the measurement and interpretation of thyroid function tests

Gurnell Mark

Accurate diagnosis of thyroid dysfunction is dependent on understanding hypothalamic–pituitary–thyroid (HPT) axis physiology and the pathophysiology that can affect this classical endocrine feedback loop. Even minor perturbations of thyroid status, which may be imperceptible to the patient and clinician, can significantly alter the relationship between circulating thyroid hormone (TH) levels and pituitary TSH such is the finely-tuned nature of the axis.<p class="...

ea0004ds1 | PPARgamma - Living up to expectations? | SFE2002

PPARgamma - LIVING UP TO EXPECTATIONS?

Gurnell M

It is less than a decade since the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARg) was first cloned, yet it has become one of the most extensively studied family members, implicated in a wide array of physiological and pathological processes ranging from adipocyte differentiation to lipid trafficking in macrophages and thyroid neoplasia. This receptor is therefore considered a key target for therapeutic modulation, as exemplified by the novel antidiab...

ea0026mte18 | (1) | ECE2011

Weird thyroid function tests

Gurnell Mark , Chatterjee Krish

Although overt thyroid disease is easily recognised, lesser disturbances of thyroid function can prove difficult to diagnose and be mimicked by other endocrine and non-endocrine disorders. Establishing the correct diagnosis depends on accurate interpretation of thyroid function tests (TFTs), which is usually straightforward; however, in a minority of situations, the results of FT4, FT3 and TSH measurement either do not ‘fit’ with the clinical picture and/or appear di...

ea0094cc7 | Section | SFEBES2023

Use of osilodrostat alongside 11C-Methionine PET CT in pituitary-dependent Cushing’s disease may improve radiological detection and lead to better outcomes

Yang Lisa , Gurnell Mark , Wernig Florian

Introduction: Pituitary – dependent Cushing’s disease accounts for approximately 80% of endogenous Cushing’s syndrome but a target lesion is only detectable on MRI in 60% of cases. 11C-methionine PET CT improves detection of indeterminate pituitary lesions. Osilodrostat is a novel steroidogenesis inhibitor which reduces cortisol levels with resultant rise in ACTH and may further enhance the sensitivity of 11C-methionine PET CT in difficult cases...

ea0094p318 | Adrenal and Cardiovascular | SFEBES2023

LH-dependent female testosterone excess persisting after bilateral oophorectomy

Scotucci Jacopo , Gurnell Mark , Powlson Andrew

A 55-year-old post-menopausal female presented with hirsutism and increased libido. Testosterone was elevated at 9.7 (RR <1.8 nmol/l). LH/FSH were appropriate post-menopause (LH 28.8; FSH 54.1U/l). DHEAS, androstenedione and 17-hydroxyprogesterone were unremarkable. GnRH analogue suppression testing (GnST) appropriately suppressed LH/FSH and testosterone (testosterone 0.2 nmol/l), suggesting an LH-dependent source of testosterone. Pelvic MRI suggested a left ovarian tumour...

ea0055p15 | Poster Presentations | SFEEU2018

A surgical treatment for cardiomyopathy

Kirresh Omar , Gurnell Mark , Drake William , Chung Teng Teng

Case history: A 59 year old Afro-Carribbean male with a 25 year history of cardiac enlargement and hypertension, on multiple anti-hypertensives, presented with increasing breathlessness and several years of markedly reduced exercise tolerance. He was intolerant of spironolactone and eplerenone. His past medical history included hypertersion, obstructive sleep apnoea, Steven-Johnson syndrome secondary to allopurinol, thyrotoxicosis treated with radio-active iodine, monoclonal g...