Searchable abstracts of presentations at key conferences in endocrinology

ea0011p512 | Endocrine tumours and neoplasia | ECE2006

Mutation at codon 804 detected in a Greek kindred by screening of the RET gene in patients with medullary thyroid carcinoma

Mytakidis N , Vassiliou E , Liakos V , Papagrigoriou L , Hadzimarkou F , Kostoglou-Athanasiou I , Koutsodontis G , Ladopoulou A , Bei T , Yannoukakos D , Kaldrymidis P

Medullary Thyroid Carcinoma (MTC) is a rare cancer that arises from the thyroid C-cells and occurs as sporadic in 75% of the cases. In 25% of MTC cases, mutations of the RET proto-oncogene are responsible for the development of three dominantly inherited neoplastic disorders including multiple endocrine neoplasia (MEN) 2A, MEN 2B and familial medullary thyroid carcinoma (FMTC). Since 2–8% of MTC cases considered sporadic conceal germline mutations, direct analysis of the ...